EHD1 and PACSIN2

Number of citations of the paper that reports this interaction (PubMedID 15371016)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		EHD1	PACSIN2
Description		EH domain containing 1	protein kinase C and casein kinase substrate in neurons 2
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Lipid Droplet Plasma Membrane Cilium Endosome Membrane Membrane Ciliary Pocket Membrane Endocytic Vesicle Platelet Dense Tubular Network Membrane Early Endosome Membrane Cell Projection Perinuclear Region Of Cytoplasm Presynaptic Active Zone Recycling Endosome Membrane Ciliary Membrane Extracellular Exosome Glutamatergic Synapse	Cytoplasm Endosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Caveola Cell-cell Junction Adherens Junction Focal Adhesion Cilium Membrane Nuclear Speck Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ruffle Membrane Centriolar Satellite Cell Projection Recycling Endosome Membrane Extracellular Exosome Anchoring Junction Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Metal Ion Binding	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Cadherin Binding Phosphatidic Acid Binding
	Biological Process	Intracellular Protein Transport Endocytosis Positive Regulation Of Cholesterol Storage Positive Regulation Of Neuron Projection Development Protein Transport Endosomal Transport Cell Projection Organization Neuron Projection Development Endocytic Recycling Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Protein Homooligomerization Cilium Assembly Protein Localization To Cilium Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Endocytic Recycling	Cell Migration Involved In Sprouting Angiogenesis Endocytosis Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Endocytosis Protein Localization To Endosome Negative Regulation Of Endocytosis Cell Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Caveola Assembly Caveolin-mediated Endocytosis Plasma Membrane Tubulation
Pathways		Factors involved in megakaryocyte development and platelet production	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Prostate cancer (SNP x SNP interaction) ( 22219177)
Interacting Genes		13 interacting genes: AP2A1 EHBP1 EHD3 HSPB1 IGF1R MICAL1 MUL1 OGT PACSIN2 RAB11FIP2 RBSN RFFL SNAP29	18 interacting genes: DNM1 EHD1 EXOSC8 FASLG GSC2 MECOM MEOX2 PACSIN1 PACSIN3 PBX4 POT1 RIC8A SHBG SYNJ1 TERF1 TERF2IP TRPV4 WASL
Entrez ID		10938	11252
HPRD ID		09325	05390
Ensembl ID		ENSG00000110047	ENSG00000100266
Uniprot IDs		A0A024R571 B2R5U3 Q9H4M9	Q6FIA3 Q9UNF0
PDB IDs		2JQ6 2KFF 2KFG 2KFH 2KSP	3ABH 3ACO 3HAJ 3Q0K
Enriched GO Terms of Interacting Partners?		Intracellular Protein Localization Vesicle-mediated Transport Protein Transport Endosome Establishment Of Protein Localization Recycling Endosome Membrane Plasma Membrane Ciliary Pocket Membrane Protein Kinase Binding Endocytosis Golgi To Lysosome Transport Cilium Endosome Membrane Import Into Cell Post-Golgi Vesicle-mediated Transport Early Endosome To Golgi Transport Regulation Of Golgi Organization Golgi To Vacuole Transport Cytosolic Transport Membrane Establishment Of Localization In Cell Negative Regulation Of Protein Kinase C Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Ciliary Membrane Cytosol Regulation Of Cellular Component Organization Cellular Response To Glucose Stimulus Golgi Vesicle Transport Small GTPase Binding Intracellular Transport P53 Binding Cellular Response To Carbohydrate Stimulus Sulfur Oxidation Hippocampal Mossy Fiber Expansion Cell Projection Early Endosome Negative Regulation Of Intracellular Signal Transduction Protein Kinase C Inhibitor Activity Insulin-like Growth Factor Receptor Activity Protein Kinase Complex Intracellular Glucose Homeostasis Insulin Receptor Activity Protein O-acetylglucosaminyltransferase Activity TRAM-dependent Toll-like Receptor 4 Signaling Pathway F-actin Monooxygenase Activity Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Retrograde Transport, Endosome To Golgi Positive Regulation Of Cold-induced Thermogenesis	Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Positive Regulation Of Cellular Component Organization Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Negative Regulation Of Cellular Component Organization Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Import Into Cell Membrane Organization Telomeric D-loop Disassembly Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Telomeric Loop Disassembly Endocytosis Negative Regulation Of Chromosome Organization Plasma Membrane Tubulation DNA Biosynthetic Process Regulation Of Plasma Membrane Organization Positive Regulation Of Organelle Organization Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Organization Lipid Binding Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Organelle Organization Negative Regulation Of DNA Biosynthetic Process Vesicle Budding From Membrane Clathrin Coat Assembly Involved In Endocytosis Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Chromosome, Telomeric Region Presynaptic Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Endosome Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Presynaptic Endocytic Zone Osmosensor Activity Blood Vessel Endothelial Cell Delamination
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