COPS8 and ITPK1

Number of citations of the paper that reports this interaction (PubMedID 12324474)
0

Data Source:
HPRD (in vitro)

		COPS8	ITPK1
Description		COP9 signalosome subunit 8	inositol-tetrakisphosphate 1-kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol Apical Plasma Membrane
	Molecular Function	Protein Binding	Nucleotide Binding Magnesium Ion Binding Inositol-1,3,4,5-tetrakisphosphate 6-kinase Activity Catalytic Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Isomerase Activity Metal Ion Binding Inositol-3,4,5,6-tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity Inositol-3,4,6-trisphosphate 1-kinase Activity
	Biological Process	Protein Deneddylation Protein Phosphorylation Activation Of NF-kappaB-inducing Kinase Activity Negative Regulation Of Cell Population Proliferation COP9 Signalosome Assembly Protein Neddylation Regulation Of Protein Neddylation	Signal Transduction Blood Coagulation Neural Tube Development Inositol Trisphosphate Metabolic Process Necroptotic Process
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Synthesis of pyrophosphates in the cytosol Synthesis of IP3 and IP4 in the cytosol Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Asthma ( 27611488) Body mass index ( 25673413) Coronary artery disease ( 33020668) Lung cancer ( 28604730) Motion sickness ( 25628336) Pulse pressure ( 27841878) Systemic lupus erythematosus ( 19838195)	Body mass index ( 26426971) Chronic obstructive pulmonary disease ( 30804561) Endometriosis ( 23472165) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) Migraine ( 27182965 27322543) Monocyte count ( 32888494) Platelet count ( 22139419 32888494) Plateletcrit ( 27863252 32888494) Spleen volume ( 34128465) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) White blood cell count ( 32888494)
Interacting Genes		19 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 DHFR EIF3E GPS1 ITPK1 MAPRE1 NFKBIA PDCD1 SUOX TP53 UBC USHBP1	6 interacting genes: COPS8 GPS1 JUN NFKBIA TP53 TRAF2
Entrez ID		10920	3705
HPRD ID		16737	03501
Ensembl ID		ENSG00000198612	ENSG00000100605
Uniprot IDs		Q99627	G3V4M9 Q13572
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F	2ODT 2Q7D 2QB5 9DN3
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Protein Modification By Small Protein Removal Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein Modification Process Cytosol Regulation Of Protein Modification Process Ubiquitin Protein Ligase Binding DeNEDDylase Activity Ubiquitin Ligase Complex Scaffold Activity Protein Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of T Cell Apoptotic Process Eukaryotic Translation Initiation Factor 3 Complex Necroptotic Process Cullin-RING Ubiquitin Ligase Complex Positive Regulation Of Lymphocyte Apoptotic Process Nucleoplasm Programmed Necrotic Cell Death T Cell Apoptotic Process Positive Regulation Of Leukocyte Apoptotic Process Lymphocyte Apoptotic Process Cytoplasm Response To Methotrexate Inositol-3,4,5,6-tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-3,4,6-trisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity Regulatory T Cell Apoptotic Process Negative Regulation Of Tolerance Induction Regulation Of T Cell Apoptotic Process Sulfite Oxidase Activity Negative Regulation Of Helicase Activity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G1 To G0 Transition Protein Localization To Astral Microtubule Protein-containing Complex Leukocyte Apoptotic Process Translation Initiation Factor Activity Dihydrofolate Reductase Activity Macromolecule Metabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Inositol-1,3,4,5-tetrakisphosphate 6-kinase Activity Tumor Necrosis Factor-mediated Signaling Pathway	Intracellular Signaling Cassette Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Ubiquitin Protein Ligase Binding Tumor Necrosis Factor-mediated Signaling Pathway Enzyme Binding Protein Deneddylation General Transcription Initiation Factor Binding Regulation Of Protein Neddylation Protein Neddylation Programmed Necrotic Cell Death Response To Muscle Stretch COP9 Signalosome Response To Endoplasmic Reticulum Stress Non-canonical NF-kappaB Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Signal Transduction Involved In Regulation Of Gene Expression Nucleoplasm Positive Regulation Of MiRNA Transcription JNK Cascade Transcription Repressor Complex Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Cytokine-mediated Signaling Pathway Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of MiRNA Transcription Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition TORC2 Complex Disassembly Regulation Of MiRNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Primary Metabolic Process Protein Modification By Small Protein Removal Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Metabolic Process Leukocyte Activation Positive Regulation Of Apoptotic Process Leading Edge Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Oligodendrocyte Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Protein Import Into Nucleus Regulation Of Protein Modification Process
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