SMR3B and SFTPD

		SMR3B	SFTPD
Description		submaxillary gland androgen regulated protein 3B	surfactant protein D
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Extracellular Region Collagen Trimer Extracellular Space Cytoplasm Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle
	Molecular Function	Endopeptidase Inhibitor Activity Protein Binding	Protein Binding Carbohydrate Binding Identical Protein Binding
	Biological Process	Regulation Of Sensory Perception Of Pain	Regulation Of Cytokine Production Immune System Process Regulation Of Immune System Process Receptor-mediated Endocytosis Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Reactive Oxygen Species Metabolic Process
Pathways			Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs			Beta-D-Glucose
Diseases
GWAS			Chronic obstructive pulmonary disease ( 28166215 30804561 33909500) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Lung function (FEV1/FVC) ( 30804560) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		5 interacting genes: HOMER3 SFTPD UBQLN1 UBQLN2 XPO1	12 interacting genes: CCN1 DCN DMBT1 GPA33 KCNMA1 LBR MFAP4 PLAU PLXNA3 RBX1 SFTPA1 SMR3B
Entrez ID		10879	6441
HPRD ID		18078	01522
Ensembl ID		ENSG00000171201	ENSG00000133661
Uniprot IDs		P02814 Q504X8	P35247
PDB IDs			1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS
Enriched GO Terms of Interacting Partners?		Regulation Of Transport Negative Regulation Of Interleukin-2 Production Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Interleukin-2 Production Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Organization Positive Regulation Of Proteasomal Protein Catabolic Process Identical Protein Binding Cellular Response To Triglyceride Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process G Protein-coupled Glutamate Receptor Binding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Vacuole Organization Response To Triglyceride Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Macroautophagy Annulate Lamellae Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Protein Domain Specific Binding Cellular Response To Salt Ribosomal Large Subunit Export From Nucleus Regulation Of Calcium Ion Transport Response To Endoplasmic Reticulum Stress Ribosomal Small Subunit Export From Nucleus Autophagy Regulation Of Macromolecule Metabolic Process Regulation Of Endocytosis Ribosomal Subunit Export From Nucleus Nuclear Export Signal Receptor Activity Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Cytokine Production Regulation Of Store-operated Calcium Entry Regulation Of Metal Ion Transport Aggrephagy Negative Regulation Of Calcineurin-NFAT Signaling Cascade G Protein-coupled Glutamate Receptor Signaling Pathway Basal Part Of Cell Negative Regulation Of Receptor Internalization	Extracellular Space Extracellular Matrix Extracellular Region Extracellular Matrix Binding
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