POLR1G and ANK3

		POLR1G	ANK3
Description		RNA polymerase I subunit G	ankyrin 3
Image
GO Annotations	Cellular Component	RNA Polymerase I Transcription Regulator Complex DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex Mitochondrion Cytosol	Cytoplasm Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Basal Plasma Membrane Cell Surface Intercalated Disc Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Sarcoplasmic Reticulum Z Disc T-tubule Axon Dendrite Neuromuscular Junction Node Of Ranvier Sarcolemma Cell Projection Neuron Projection Costamere Axon Initial Segment Organelle Synapse Postsynaptic Membrane
	Molecular Function	RNA Binding Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Cytoskeletal Anchor Activity Sodium Channel Regulator Activity Spectrin Binding Protein-macromolecule Adaptor Activity Transmembrane Transporter Binding Cadherin Binding Channel Activator Activity
	Biological Process	Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway RRNA Transcription	Mitotic Cytokinesis Plasma Membrane Organization Cytoskeleton Organization Signal Transduction Axonogenesis Neuromuscular Junction Development Positive Regulation Of Gene Expression Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Sodium Ion Transport Magnesium Ion Homeostasis Neuronal Action Potential Positive Regulation Of Homotypic Cell-cell Adhesion Golgi To Plasma Membrane Protein Transport Regulation Of Potassium Ion Transport Establishment Of Protein Localization Positive Regulation Of Membrane Potential Golgi Vesicle Transport Cellular Response To Magnesium Ion Membrane Assembly Protein Localization To Plasma Membrane Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Protein Localization To Axon Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins COPI-mediated anterograde transport Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Behavioral disturbance or psychiatric symptoms and prion disease ( 25897833) Bipolar disorder ( 18711365 33263727 31043756 34002096 28072414 24618891 22182935 21926972 20351715) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Diastolic blood pressure ( 30224653) Frailty index ( 34431594) Heel bone mineral density ( 30598549) Height ( 31562340) Metabolite levels ( 23823483) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457) Psychotic experience ( 31553412) Refractive error ( 32231278) Schizophrenia ( 20185149) Third ventricle volume ( 31530798) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)
Interacting Genes		7 interacting genes: ANK3 CD3E NFKBIB POLR1C POLR1E TAF1A UBTF	31 interacting genes: ENO1 FADD FAS FTH1 GABARAP GRM4 HOOK1 KCNC1 MAP1LC3A MAP1LC3C MAPK6 MBL2 NAB2 NEDD4 PIK3R1 PLEC POLR1G RIPK4 RNF10 SCN1B SCN2A SCNN1B SGPL1 SMAD2 SMAD3 SPTBN4 SRPK2 TACR2 UBE2D1 XPNPEP1 YAP1
Entrez ID		10849	288
HPRD ID		00125	02715
Ensembl ID		ENSG00000117877	ENSG00000151150
Uniprot IDs		O15446	Q12955 Q8NAK2
PDB IDs		7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43	4O6X
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase I DNA-templated Transcription Transcription Initiation At RNA Polymerase I Promoter Nucleobase-containing Compound Biosynthetic Process RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase I Complex Fibrillar Center RNA Metabolic Process Macromolecule Biosynthetic Process DNA-directed RNA Polymerase Complex Nucleolus Transcription Preinitiation Complex Assembly Nucleic Acid Metabolic Process DNA-templated Transcription Initiation RNA Polymerase I General Transcription Initiation Factor Binding Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Protein Location In Plasma Membrane RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Cell Communication By Electrical Coupling Gamma-delta T Cell Receptor Complex Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulator Complex T Cell Anergy Regulation Of Glucose Mediated Signaling Pathway Nucleolar Large RRNA Transcription By RNA Polymerase I Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential RNA Polymerase I General Transcription Initiation Factor Activity RNA Polymerase Transcription Factor SL1 Complex Cellular Response To Magnesium Ion Positive Regulation Of T Cell Anergy Positive Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Tolerance Induction Protein-DNA Complex Assembly Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Channel Activator Activity Regulation Of Membrane Depolarization During Action Potential Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Alpha-beta T Cell Receptor Complex Signal Complex Assembly Regulation Of T Cell Anergy Transcription Elongation By RNA Polymerase I Regulation Of Delayed Rectifier Potassium Channel Activity CD4-positive, Alpha-beta T Cell Proliferation RNA Polymerase I Core Promoter Sequence-specific DNA Binding Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Membrane Potential Protein Localization To Axon	Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Nitrogen Starvation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Phosphatidylethanolamine Binding Node Of Ranvier Paraxial Mesoderm Morphogenesis SMAD Protein Signal Transduction Autophagosome Signal Transduction Response To Nutrient Levels Protein-containing Complex Organization Mesoderm Morphogenesis CD95 Death-inducing Signaling Complex Pericardium Development Death-inducing Signaling Complex SMAD Protein Complex Trophoblast Cell Migration Sodium Channel Complex Phospholipid Binding Cellular Response To Nutrient Levels Heteromeric SMAD Protein Complex Ameboidal-type Cell Migration Sodium Channel Inhibitor Activity Autophagosome Maturation Necroptotic Signaling Pathway Phosphatase Binding Autophagosome Membrane Negative Regulation Of Programmed Cell Death Cytosol Embryonic Foregut Morphogenesis Mitophagy Mesenchyme Development Regulation Of Programmed Cell Death Autolysosome Nodal Signaling Pathway Co-SMAD Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Nucleocytoplasmic Transport Voltage-gated Sodium Channel Complex Primary MiRNA Processing Regulation Of Sodium Ion Transport Vacuole Organization Cellular Response To Starvation Motor Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Regulation Of Biological Quality Transforming Growth Factor Beta Receptor Binding Wound Healing Sodium Ion Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?