NCKAP1 and MYO16

Number of citations of the paper that reports this interaction (PubMedID 21946561)
80

Data Source:
BioGRID (pull down)

		NCKAP1	MYO16
Description		NCK associated protein 1	myosin XVI
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytosol Plasma Membrane Focal Adhesion Membrane Lamellipodium SCAR Complex Lamellipodium Membrane Filamentous Actin Cell Projection Extracellular Exosome Postsynapse	Nucleoplasm Cytoplasm Plasma Membrane Myosin Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Small GTPase Binding	Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding ATP Binding Protein Phosphatase Binding Actin Filament Binding
	Biological Process	Cell Morphogenesis In Utero Embryonic Development Somitogenesis Neural Tube Closure Apoptotic Process Zygotic Determination Of Anterior/posterior Axis, Embryo Central Nervous System Development Endoderm Development Mesodermal Cell Migration Embryonic Body Morphogenesis Positive Regulation Of Lamellipodium Assembly Cell Migration Rac Protein Signal Transduction Cell Projection Assembly Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Notochord Development Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Protein Localization Embryonic Heart Tube Development Cell Migration Involved In Gastrulation Basal Protein Localization Apical Protein Localization Paraxial Mesoderm Development Paraxial Mesoderm Morphogenesis Notochord Morphogenesis Embryonic Foregut Morphogenesis Neuron Projection Morphogenesis Protein Stabilization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Negative Regulation Of Cell Population Proliferation Cerebellum Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Projection Morphogenesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Neurological blood protein biomarker levels ( 31320639)	Alzheimer's disease ( 30636644) Alzheimer's disease (cognitive decline) ( 23535033) Blood pressure ( 22763476) Chronotype ( 30696823) Colorectal cancer ( 29228715) Dental caries ( 23064961) Eosinophil count ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Ferritin levels ( 33491795) Lung function (FEV1/FVC) ( 30804560) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Nose size ( 27182965) Obesity-related traits ( 23251661) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Presence of antiphospholipid antibodies ( 23509613) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 32888494) Resting-state electroencephalogram vigilance ( 29703947) Seasonality ( 25562672) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		16 interacting genes: ABI1 BRK1 CYFIP2 DNMBP GAS7 MYO16 NCK1 NYAP1 NYAP2 RAC1 SPP1 TMEM132D WASF1 WASF2 WEE2-AS1 YWHAG	7 interacting genes: CYFIP1 DAOA NCKAP1 NRXN1 PIK3R1 PPP1CA PPP1CC
Entrez ID		10787	23026
HPRD ID		05353	14795
Ensembl ID		ENSG00000061676	ENSG00000041515
Uniprot IDs		A0A994J4I5 A0A994J6K9 Q9Y2A7	F8W883 Q9Y6X6
PDB IDs		3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		SCAR Complex Cell Projection Morphogenesis Cell Projection Organization Lamellipodium Organization Rac Protein Signal Transduction Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Actin Nucleation Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Anatomical Structure Morphogenesis Positive Regulation Of Lamellipodium Assembly Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Filament Organization Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Lamellipodium Assembly Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Intracellular Signaling Cassette Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Intracellular Signal Transduction Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Synapse Regulation Of Lamellipodium Organization Cell Projection Assembly Actin Polymerization Or Depolymerization Signal Transduction Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Supramolecular Fiber Organization Regulation Of Cellular Component Size Positive Regulation Of Organelle Organization Arp2/3 Complex Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Polymerization Megakaryocyte Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding	Positive Regulation Of Lamellipodium Assembly Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Organization Postsynapse PTW/PP1 Phosphatase Complex Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation SCAR Complex Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Actin Nucleation Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Rac Protein Signal Transduction Photoperiodism Entrainment Of Circadian Clock Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Protein Stabilization Presynapse Lamellipodium Assembly Regulation Of Actin Nucleation Regulation Of Actin Filament Organization Lamellipodium Organization Regulation Of Filopodium Assembly Intracellular Signaling Cassette Response To Light Stimulus Glycogen Metabolic Process Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Stability Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Projection Organization Regulation Of Actin Filament-based Process Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Phosphatase Activity Polysaccharide Metabolic Process Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Focal Adhesion Positive Regulation Of Protein Localization To Membrane Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity
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