NES and CDK5R1

Number of citations of the paper that reports this interaction (PubMedID 12832492)
43

Data Source:
HPRD (in vivo)

		NES	CDK5R1
Description		nestin	cyclin dependent kinase 5 regulatory subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Intermediate Filament Intermediate Filament Cytoskeleton	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Axon Dendrite Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Contractile Muscle Fiber Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Intermediate Filament Binding CCR5 Chemokine Receptor Binding	Protease Binding Actin Binding Protein Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Protein Kinase Binding Protein Kinase Activator Activity Ionotropic Glutamate Receptor Binding Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Beta-tubulin Binding Actin Filament Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Nervous System Development Central Nervous System Development Brain Development Positive Regulation Of Intermediate Filament Depolymerization Embryonic Camera-type Eye Development Negative Regulation Of Protein Binding Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Cell Projection Morphogenesis Neuron Apoptotic Process Stem Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization Neuron Migration Neuron Cell-cell Adhesion G Protein-coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Cerebral Cortex Radially Oriented Cell Migration Layer Formation In Cerebral Cortex Neuron Differentiation Positive Regulation Of Microtubule Polymerization Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of MHC Class II Biosynthetic Process Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis G1 To G0 Transition Involved In Cell Differentiation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways			CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription NGF-stimulated transcription Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes
Drugs			Indirubin-3'-monoxime 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS
Interacting Genes		3 interacting genes: CDK1 CDK5 CDK5R1	37 interacting genes: ACTN1 AMPH APP BCL2L13 BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 FEM1B FEM1C HNF1B HSP90AA1 KRT40 KRTAP10-3 LMTK2 MAPT MTUS2 NEDD4 NES NOTCH2NLA ODF1 PAK1 SEPTIN5 SET SIAH1 STXBP1 SUZ12 TSC22D4 TTBK1
Entrez ID		10763	8851
HPRD ID		09020	04586
Ensembl ID		ENSG00000132688	ENSG00000176749
Uniprot IDs		P48681 Q9H6U9	Q15078 Q8N619
PDB IDs			1H4L 1UNG 1UNH 1UNL 3O0G 6LDP 7CNG 7VDP 7VDQ 7VDR 7VDS
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Kinase 5 Complex Peptidyl-threonine Phosphorylation Rhythmic Process Layer Formation In Cerebral Cortex Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Targeting To Membrane Cyclin-dependent Protein Serine/threonine Kinase Activity Ionotropic Glutamate Receptor Binding Regulation Of Protein Targeting To Membrane Microtubule Cytoskeleton Organization Regulation Of Dendritic Spine Morphogenesis Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Protein Kinase Activity Cerebellum Development Kinase Activity Positive Regulation Of Neuron Apoptotic Process Hippocampus Development Neuromuscular Junction Microtubule-based Process Plasma Membrane Bounded Cell Projection Organization Regulation Of Nucleocytoplasmic Transport Cell Migration Regulation Of Protein Localization Pronuclear Fusion Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Cytoskeleton Organization Growth Cone Regulation Of Postsynapse Organization Neuron Migration Perikaryon Regulation Of Intracellular Protein Transport Cell Motility Cell Projection Organization Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Acetylcholine Receptor Activator Activity Superior Olivary Nucleus Maturation Regulation Of Macroautophagy Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity ErbB-2 Class Receptor Binding Neuron Projection Guidance Negative Regulation Of Synaptic Plasticity Axon Guidance	Regulation Of Apoptotic Process Cytoplasm Developmental Process Cytosol Regulation Of Programmed Cell Death Positive Regulation Of Protein Polymerization Receptor Metabolic Process Acetylcholine Receptor Activator Activity Protein Kinase Binding Neurofibrillary Tangle Assembly Neuron Projection Development Protein Serine Kinase Activity Receptor Catabolic Process Developmental Growth Involved In Morphogenesis Apoptotic Process Regulation Of Neuron Apoptotic Process Regulation Of Developmental Process Perinuclear Region Of Cytoplasm Regulation Of Protein Localization Programmed Cell Death Cell Death Protein Serine/threonine Kinase Activity Establishment Of Organelle Localization Calpain Complex Cyclin-dependent Protein Serine/threonine Kinase Activity Amyloid Fibril Formation Cellular Developmental Process Regulation Of Neurotransmitter Secretion Main Axon Vesicle-mediated Transport In Synapse Positive Regulation Of Microtubule Polymerization Dendrite Organelle Localization Cell Differentiation Establishment Of Localization In Cell Regulation Of Cell Differentiation Synaptic Vesicle Transport NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Cell Projection Organization Establishment Of Vesicle Localization Synaptic Vesicle Endocytosis Protein Kinase Activity Neuron Apoptotic Process Neuronal Cell Body Presynaptic Endocytosis Tau Protein Binding Oligodendrocyte Differentiation Developmental Cell Growth
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