MAP3K2 and STAMBP

Number of citations of the paper that reports this interaction (PubMedID 24975362)
38

Data Source:
BioGRID (enzymatic study)

		MAP3K2	STAMBP
Description		mitogen-activated protein kinase kinase kinase 2	STAM binding protein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Cleavage Furrow Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Protein Domain Specific Binding Metal Ion Binding K63-linked Deubiquitinase Activity Deubiquitinase Activity Metal-dependent Deubiquitinase Activity
	Biological Process	MAPK Cascade Intracellular Signal Transduction Cellular Response To Mechanical Stimulus	Mitotic Cytokinesis Proteolysis Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Protein Deubiquitination Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K63-linked Deubiquitination Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process
Pathways			Metalloprotease DUBs
Drugs		Bosutinib Fostamatinib
Diseases
GWAS		Protein C levels ( 28082259)	Anti-saccade response ( 29064472) Bell's palsy ( 33602968) Blood metabolite levels ( 26401656) Serum metabolite levels ( 23093944 33031748)
Interacting Genes		28 interacting genes: BIRC2 CTNNB1 IKBKG ITCH LATS1 MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NFKBIA NGLY1 PIBF1 PKN2 SH2D2A SMURF1 SMYD3 STAMBP STUB1 USP2 WNK1 XIAP YAP1 YWHAE YWHAG YWHAZ	51 interacting genes: ALAS1 AMN APOBEC3A ATG14 BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 DSCR9 EGFR EPS15 GRAP2 GRB2 IL1RL2 ITGA5 MAP2K5 MAP3K2 MLKL NLRP7 NTPCR PJA1 RBM11 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SNCA SPG7 STAM STAM2 TNFRSF1A TP53 TRAF6 TRIP13 UACA UBC UBE2S ULK1 USP21 USP28 VHL
Entrez ID		10746	10617
HPRD ID		10068	05877
Ensembl ID		ENSG00000169967	ENSG00000124356
Uniprot IDs		Q9Y2U5	A0A140VK54 A0A804HIF8 A0A804HII8 A0A804HJ64 O95630
PDB IDs		2CU1 2NPT 5EX0 5HQ8 6LDV 6LDW 6LDX 6LDY	2XZE 3RZU 3RZV 5IXF
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Cellular Response To Stress Signal Transduction Protein Modification Process Positive Regulation Of Protein Metabolic Process Cytosol Protein Polyubiquitination Cytoplasm Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Transferase Activity Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Post-translational Protein Modification Protein Serine Kinase Activity Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Signaling Pathway MAP Kinase Kinase Activity Protein Phosphatase Binding Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Immune Response Response To Stress Immune Response-regulating Signaling Pathway Regulation Of Protein Modification Process Regulation Of Immune System Process Positive Regulation Of Signal Transduction Cellular Senescence Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Protein Domain Specific Binding Protein Kinase Activity Stress-activated Protein Kinase Signaling Cascade Phosphoserine Residue Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Modification-dependent Protein Catabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway	ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body Organization Multivesicular Body Assembly Multivesicular Body-lysosome Fusion Viral Budding From Plasma Membrane Late Endosome To Vacuole Transport Lysosomal Membrane Organization Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Late Endosome To Lysosome Transport Kinetochore Microtubule Autophagosome Membrane Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Regulation Of Mitotic Spindle Organization Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Endosome Organization Regulation Of Spindle Assembly Autophagy Cytokinetic Process Protein-containing Complex Disassembly Endosomal Transport Multivesicular Body Mitotic Metaphase Chromosome Alignment Biological Process Involved In Interaction With Host Nuclear Membrane Organization Vacuolar Transport Vacuole Organization Metaphase Chromosome Alignment Membrane Assembly Endosome Macroautophagy Regulation Of Microtubule Cytoskeleton Organization Chromosome Localization Lysosomal Transport Regulation Of Centrosome Duplication Nuclear Pore Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Nucleus Organization
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