SIX2 and EYA3

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SIX2	EYA3
Description		SIX homeobox 2	EYA transcriptional coactivator and phosphatase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm Centrosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Histone H2AXY142 Phosphatase Activity
	Biological Process	Metanephros Development Kidney Development Chondrocyte Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Mesodermal Cell Fate Specification Cell Population Proliferation Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Cell Migration Regulation Of Ossification Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Regulation Of Chondrocyte Differentiation Middle Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Nephron Development Nephron Morphogenesis Mesenchymal Stem Cell Maintenance Involved In Nephron Morphogenesis Condensed Mesenchymal Cell Proliferation Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Mesenchymal Stem Cell Proliferation Positive Regulation Of Chondrocyte Proliferation	DNA Repair Double-strand Break Repair Chromatin Organization Chromatin Remodeling DNA Damage Response Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Cell Differentiation Positive Regulation Of DNA Repair Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Formation of the ureteric bud	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Blood sugar levels ( 29403010) Clozapine-induced myocarditis in schizophrenia ( 32066683) Fasting blood glucose ( 29621232 33842983) Fasting plasma glucose ( 25187374) Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Lung cancer ( 28604730) Metabolite levels ( 21909109) Refractive error ( 32231278) Retinal arteriole-to-venule ratio ( 31597446)	Plasma trimethylamine N-oxide levels ( 28439531) Total cholesterol levels ( 30275531)
Interacting Genes		7 interacting genes: APP CDKN2A CLIP4 EYA1 EYA3 TLE1 TLE5	9 interacting genes: CRK DACH1 DSCAM DSCR9 SIX1 SIX2 SIX4 SIX5 ZDHHC17
Entrez ID		10736	2140
HPRD ID		05408	09042
Ensembl ID		ENSG00000170577	ENSG00000158161
Uniprot IDs		Q8TBA2 Q9NPC8	Q99504
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H2AXY142 Phosphatase Activity Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Stress Regulation Of Anoikis Amyloid Fibril Formation Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Signal Transduction Protein Sumoylation Regulation Of Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Signaling Pathway Ligase Inhibitor Activity Otic Vesicle Morphogenesis Response To Interleukin-1 Response To Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Protein Tyrosine Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Apoptotic Process Nucleus Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization	Transcription Regulator Complex Regulation Of Branching Involved In Ureteric Bud Morphogenesis Fungiform Papilla Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Branch Elongation Involved In Ureteric Bud Branching Olfactory Placode Formation Regulation Of Kidney Development Myotome Development Positive Regulation Of Ureteric Bud Formation Trigeminal Ganglion Development Cranial Ganglion Development Regulation Of Morphogenesis Of A Branching Structure Tongue Development Regulation Of Morphogenesis Of An Epithelium Metanephric Mesenchyme Development Regulation Of Animal Organ Morphogenesis Embryonic Skeletal System Morphogenesis Positive Regulation Of Epithelial Tube Formation Regulation Of Synaptic Assembly At Neuromuscular Junction Cell Population Proliferation Regulation Of Skeletal Muscle Satellite Cell Proliferation Myoblast Migration Skeletal System Morphogenesis Regulation Of Skeletal Muscle Cell Proliferation Ganglion Development Embryonic Organ Morphogenesis Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Pharyngeal System Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Generation Of Neurons Middle Ear Morphogenesis Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Skeletal Muscle Cell Differentiation Mesenchymal Cell Proliferation Muscle Cell Migration Protein Localization To Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Growth Positive Regulation Of Morphogenesis Of An Epithelium Protein Tyrosine Kinase Binding DNA-binding Transcription Factor Activity Thymus Development Developmental Process Anatomical Structure Morphogenesis Mesenchyme Development Regulation Of Synapse Organization Inner Ear Morphogenesis Regulation Of Transcription By RNA Polymerase II
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