NUDC and HPCA

		NUDC	HPCA
Description		nuclear distribution C, dynein complex regulator	hippocalcin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Midbody Mitotic Spindle	Cytoplasm Cytosol Membrane Axon Dendrite Membrane Neuronal Cell Body Membrane Dendrite Cytoplasm Perikaryon Dendritic Spine Head Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Cadherin Binding Unfolded Protein Binding	Actin Binding Calcium Ion Binding Protein Binding Kinase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Folding Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Nuclear Migration Response To Peptide Hormone Cell Division Establishment Of Organelle Localization	Regulation Of Signal Transduction Calcium-mediated Signaling Inner Ear Development Retina Development In Camera-type Eye Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Protein Targeting To Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Response To Ketamine Response To L-glutamate Response To Aroclor 1254 Cellular Response To L-glutamate
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation RND2 GTPase cycle
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Lipoprotein (a) levels ( 33730874) Plateletcrit ( 27863252)	Daytime nap ( 33568662)
Interacting Genes		10 interacting genes: ACD CEBPA HPCA NAGK OGT PAFAH1B1 PLK1 POT1 TINF2 TUBE1	29 interacting genes: AP2B1 APC BMP8B C1QTNF2 CKMT1A CKMT1B CREM CSF3R DPYD DTX2 E2F2 GATA5 IL36RN MLLT10 MYDGF NAIP NDC80 NMT1 NUDC PRR35 RAE1 RUNX3 SLC16A3 TEPSIN TMEM54 TNFRSF8 TUBA4A UQCRB VWC2
Entrez ID		10726	3208
HPRD ID		10122	00811
Ensembl ID		ENSG00000090273	ENSG00000121905
Uniprot IDs		Q9Y266	P84074
PDB IDs		3QOR 7NDX	5G4P 5G58 5M6C 7OWM
Enriched GO Terms of Interacting Partners?		Telomere Assembly Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Negative Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Organelle Organization Regulation Of Chromosome Organization Positive Regulation Of Telomere Maintenance Microtubule Organizing Center Organization Regulation Of DNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Positive Regulation Of Chromosome Organization Protein Localization To Chromosome Chromosome Organization Regulation Of Telomere Maintenance Nuclear Membrane Disassembly Membrane Disassembly Telomere Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA-templated DNA Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Intracellular Signal Transduction Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Regulation Of Organelle Organization Protein Localization To Organelle Centrosome Cycle Nuclear Membrane Organization Microtubule Cytoskeleton	Phosphocreatine Biosynthetic Process Creatine Kinase Activity
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