POLD3 and REV1

Number of citations of the paper that reports this interaction (PubMedID 26982350)
85

Data Source:
BioGRID (pull down)

		POLD3	REV1
Description		DNA polymerase delta 3, accessory subunit	REV1 DNA directed polymerase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Zeta DNA Polymerase Complex Delta DNA Polymerase Complex	Nucleus Nucleoplasm
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Protein-macromolecule Adaptor Activity	DNA Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity Deoxycytidyl Transferase Activity Metal Ion Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair DNA Damage Response Error-prone Translesion Synthesis DNA Biosynthetic Process DNA Synthesis Involved In UV-damage Excision Repair	DNA Metabolic Process DNA Replication DNA Repair DNA Damage Response Response To UV Error-prone Translesion Synthesis Error-free Translesion Synthesis DNA Biosynthetic Process
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis
Drugs
Diseases
GWAS		Colorectal cancer ( 22634755 25990418 26151821 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Hand grip strength ( 29313844 29691431) Microalbuminuria ( 26631737) Renal underexcretion gout ( 32238385) Response to metformin (IC50) ( 28173075)	Bipolar disorder ( 21926972)
Interacting Genes		7 interacting genes: APP MBD3L2 PCNA POLD1 POLD2 POLD4 REV1	14 interacting genes: CLK1 FAAP20 FHL2 GPR45 MAD2L2 POLD3 POLDIP2 POLH POLI POLK POLL REV3L TSC22D2 UBC
Entrez ID		10714	51455
HPRD ID		11446	16202
Ensembl ID		ENSG00000077514	ENSG00000135945
Uniprot IDs		Q15054	Q49AI5 Q9UBZ9
PDB IDs		1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB	2EBW 2LSI 2LSK 2LSY 2N1G 3GQC 3VU7 4BA9 4EXT 4GK0 4GK5 5VZM 6ASR 6AXD 6WS0 6WS5
Enriched GO Terms of Interacting Partners?		DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Translesion Synthesis Delta DNA Polymerase Complex Postreplication Repair DNA Replication DNA-directed DNA Polymerase Activity DNA Repair DNA-templated DNA Replication Error-free Translesion Synthesis Damaged DNA Binding DNA Metabolic Process Response To Light Stimulus DNA Damage Response Nucleobase-containing Compound Biosynthetic Process Error-prone Translesion Synthesis DNA Strand Elongation Involved In DNA Replication Base-excision Repair, Gap-filling Response To Radiation DNA Strand Elongation Response To UV Macromolecule Biosynthetic Process Cellular Response To Stress Response To Stress Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway PCNA Complex Replisome Nucleic Acid Metabolic Process Deoxycytidyl Transferase Activity DNA Binding Cellular Response To UV Nucleotidyltransferase Activity Chromatin Binding Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Cellular Response To Light Stimulus Purine-specific Mismatch Base Pair DNA N-glycosylase Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production	Translesion Synthesis Postreplication Repair DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Error-prone Translesion Synthesis DNA-directed DNA Polymerase Activity DNA Polymerase Activity DNA Repair DNA Metabolic Process DNA Replication DNA Damage Response Zeta DNA Polymerase Complex Nucleobase-containing Compound Biosynthetic Process Nucleotidyltransferase Activity Macromolecule Biosynthetic Process Cellular Response To Stress Nucleic Acid Metabolic Process Error-free Translesion Synthesis Nucleotide-excision Repair, DNA Gap Filling Damaged DNA Binding Response To Stress Nucleobase-containing Compound Metabolic Process Site Of Double-strand Break Nucleoplasm Nucleus Somatic Diversification Of Immunoglobulins Double-strand Break Repair DNA-templated DNA Replication DNA Damage Response, Signal Transduction Resulting In Transcription Macromolecule Metabolic Process Transferase Activity Atrial Cardiac Muscle Cell Development Cellular Response To UV DNA Synthesis Involved In UV-damage Excision Repair Delta DNA Polymerase Complex Cellular Response To Light Stimulus Cellular Response To UV-C DNA Binding Vascular Associated Smooth Muscle Cell Proliferation
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