KLF1 and SMARCC1

Number of citations of the paper that reports this interaction (PubMedID 11018012)
56

Data Source:
HPRD (in vitro)

		KLF1	SMARCC1
Description		KLF transcription factor 1	SWI/SNF related BAF chromatin remodeling complex subunit C1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Kinetochore Chromatin Male Germ Cell Nucleus XY Body Nucleus Nucleoplasm Cytoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex Brahma Complex NpBAF Complex NBAF Complex GBAF Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding	Chromatin Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Erythrocyte Differentiation Protein Destabilization Positive Regulation Of DNA-templated Transcription Maternal Process Involved In Female Pregnancy Cellular Response To Endothelin	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Regulation Of Mitotic Metaphase/anaphase Transition Prostate Gland Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways			RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases		Congenital dyserythropoietic anemias (CDAs)
GWAS		Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 29403010 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Age at first birth ( 34211149) Household income (MTAG) ( 31844048) Renal underexcretion gout ( 32238385) Systolic blood pressure ( 31928498) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		32 interacting genes: ARID1A C1QBP CCDC57 CREBBP CSNK2A1 CSNK2A2 DVL3 EFEMP2 EP300 FLI1 GYS1 HDAC1 HNRNPF HNRNPK MKRN3 PATZ1 PCBP1 PRKACA PRR3 RBM10 RBM4B RBPMS2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SNRPC TIAL1 TLE5 VPS37C	54 interacting genes: ADAMTSL4 AKT1 CCNE1 CEBPB CFP CIDEB CYSRT1 EWSR1 FANCA FUS GATA1 GLRX3 GSTO2 ITCH KLF1 KRTAP13-3 KRTAP19-2 KRTAP21-2 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 LRP2BP MGAT5B MSL1 MYC NCOA1 NEDD4 NONO NR3C1 OTX1 PLSCR1 PPIP5K2 PTH1R RELB SIN3A SLC15A2 SMARCA4 SMARCD3 SP1 SPATA12 SREBF1 STT3B TAF15 TRIM42 UFSP1 USP7 VGLL3 ZNF581
Entrez ID		10661	6599
HPRD ID		07197	03435
Ensembl ID		ENSG00000105610	ENSG00000173473
Uniprot IDs		Q13351	Q58EY4 Q92922
PDB IDs		2L2I 2MBH 2N23	2YUS 5GJK 6KZ7 6YXO 6YXP
Enriched GO Terms of Interacting Partners?		NpBAF Complex NBAF Complex Nucleosome Disassembly Protein-DNA Complex Disassembly Regulation Of Nucleotide-excision Repair SWI/SNF Complex Brahma Complex Regulation Of Double-strand Break Repair RSC-type Complex Regulation Of G0 To G1 Transition Regulation Of Chromosome Segregation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Stem Cell Population Maintenance BBAF Complex Regulation Of DNA Repair Positive Regulation Of Double-strand Break Repair Positive Regulation Of T Cell Differentiation Regulation Of Stem Cell Population Maintenance Nucleosomal DNA Binding Regulation Of Myoblast Differentiation Regulation Of Cellular Response To Stress Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of DNA Repair Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of Sister Chromatid Segregation Regulation Of T Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Activity Chromatin Positive Regulation Of Leukocyte Differentiation Regulation Of RNA Metabolic Process Nucleosome Organization Regulation Of Lymphocyte Differentiation Nucleoplasm Protein-containing Complex Disassembly Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Cell Adhesion Chromatin Remodeling Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Biosynthetic Process Positive Regulation Of T Cell Activation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Positive Regulation Of DNA Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle G1/S Phase Transition	Intermediate Filament Transcription Coregulator Binding Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein-containing Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Cellular Response To Hormone Stimulus Rhythmic Process Chromatin Binding Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MiRNA Transcription Protein Binding DNA-binding Transcription Factor Activity Protein-DNA Complex Disassembly Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex Positive Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Ketone Identical Protein Binding Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Nuclear Receptor-mediated Corticosteroid Signaling Pathway DNA Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Keratin Filament Cellular Response To Peptide Hormone Stimulus Regulation Of Primary Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Alpha-beta T Cell Activation Transcription By RNA Polymerase II Positive Regulation Of Innate Immune Response Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Innate Immune Response Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Defense Response Regulation Of Signal Transduction By P53 Class Mediator Protein K29-linked Ubiquitination Progesterone Receptor Signaling Pathway Response To Hormone Transcription Coregulator Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?