KHDRBS3 and CCDC187

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KHDRBS3	CCDC187
Description		KH RNA binding domain containing, signal transduction associated 3	coiled-coil domain containing 187
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Protein-containing Complex	Centrosome
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding SH3 Domain Binding Protein Domain Specific Binding Identical Protein Binding	Microtubule Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome	Microtubule Anchoring
Pathways		PTK6 Regulates Proteins Involved in RNA Processing	RHOC GTPase cycle
Drugs
Diseases
GWAS		Chronotype ( 30696823) Colorectal cancer ( 34062886) Disease progression in age-related macular degeneration ( 29346644) Polycystic ovary syndrome ( 25574032) Squamous cell lung carcinoma ( 28604730) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		60 interacting genes: AQP1 BAHD1 CACNA1A CCDC187 CCDC33 CNNM3 CPSF7 DMRT3 DOCK2 FBXO7 FUS FXR1 HBZ HNRNPC HNRNPK HNRNPR INPP5D KHDRBS1 KHDRBS2 LMNTD2 LNX1 MARK4 MYPOP NCOA5 NELFB NUDT18 OGT PCDHB14 PPP1R13B PRMT1 PRPF31 PRR3 PSMA1 PSMF1 PTBP2 RASAL3 RASD1 RBBP6 RBM3 RBM7 RBMX RBMY1A1 RFC3 RPH3AL SGSM2 SIAH1 SLIT3 SNRPC SNX18 SRSF9 TSGA10IP TYK2 U2AF2 WWP2 YTHDC1 ZNF326 ZNF408 ZNF575 ZNF580 ZNF688	72 interacting genes: ACTN2 ANKRD28 AP2B1 ASB15 BICD2 CARD10 CBY2 CCDC102B CCDC136 CCNDBP1 CDR2 CDR2L CEP63 CEP70 COG6 CRACR2B CSNK2B CYSRT1 DDX17 DEUP1 EFS FRYL FSD2 FXR1 GOLGA2 GOLGA6A GOLGA6L9 GRIPAP1 HMBOX1 HNRNPK HOMER3 HOMEZ HOOK2 HSF2BP IKZF3 INSC KHDRBS3 KIFC3 KRT15 KRT27 KRT31 KRT32 KRTAP6-1 LZTS1 LZTS2 MAGEA6 MCC MDFI MID2 MKRN3 MSS51 MTUS2 NAB2 NCKIPSD PICK1 PLEKHG4 PNMA1 PNMA3 PRKAR1B RINT1 SORBS3 SSX2IP TFIP11 TRAF1 TRAF2 TRIM27 TRIM54 TRIP6 USHBP1 VIM VPS52 ZRANB1
Entrez ID		10656	399693
HPRD ID		10007	14668
Ensembl ID		ENSG00000131773	ENSG00000260220
Uniprot IDs		O75525	A0A096LP49 A0A1W2PQX5
PDB IDs		5EL3 5ELR 5ELS 5ELT 5EMO
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing MRNA Processing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing Regulation Of MRNA Processing RNA Processing MRNA Binding RNA Binding Regulation Of MRNA Metabolic Process MRNA Metabolic Process Spliceosomal Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Negative Regulation Of MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Splicing Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Poly(U) RNA Binding Protein-RNA Complex Assembly MRNA Alternative Polyadenylation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Commitment Complex Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleoplasm Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Translation Catalytic Step 2 Spliceosome Protein-containing Complex Assembly Positive Regulation Of NK T Cell Activation Protein Binding	Protein Domain Specific Binding Protein Binding Identical Protein Binding Cytoskeleton Intermediate Filament Intermediate Filament Organization Organelle Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Cytoplasm Structural Constituent Of Skin Epidermis De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Cytosol Microtubule Organizing Center Organization Microtubule
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