CCT4 and CFAP52

Number of citations of the paper that reports this interaction (PubMedID 15967112)
37

Data Source:
HPRD (in vivo)

		CCT4	CFAP52
Description		chaperonin containing TCP1 subunit 4	cilia and flagella associated protein 52
Image
GO Annotations	Cellular Component	Zona Pellucida Receptor Complex Nucleoplasm Cytoplasm Centrosome Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Melanosome Cell Projection Cell Body Extracellular Exosome	Cytoplasm Cytoskeleton Axonemal Microtubule Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Sperm Midpiece 9+2 Motile Cilium Axonemal B Tubule Inner Sheath
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Protein Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization ScaRNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Spermatogenesis Spermatid Development Single Fertilization Gene Expression Flagellated Sperm Motility Microtubule Sliding Establishment Of Left/right Asymmetry
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Erectile dysfunction ( 30583798) Plasma free amino acid levels ( 30659259)
Interacting Genes		17 interacting genes: ACTA1 ACTA2 ACTB CCNE1 CCNH CEBPA CFAP52 LINC00624 LINC01554 MTDH OGT PRPF40A PTEN RPS6KA1 SUMO2 VRK2 WDPCP	3 interacting genes: BRCA2 CCT4 HSPA1A
Entrez ID		10575	146845
HPRD ID		05506	14072
Ensembl ID		ENSG00000115484	ENSG00000166596
Uniprot IDs		P50991	Q8N1V2
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9Q 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT	7UNG 8J07
Enriched GO Terms of Interacting Partners?		Mesenchyme Migration Positive Regulation Of Hepatic Stellate Cell Activation Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Matrix Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Proteolysis Lamellipodium Regulation Of Fibroblast Migration Protein Kinase Binding Protein-containing Complex Positive Regulation Of Hepatic Stellate Cell Contraction Positive Regulation Of Cell Activation Regulation Of Cell Cycle Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Phase Transition Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Organelle Envelope Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Axonemal Basal Plate Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of RNA Metabolic Process Regulation Of Developmental Process Cell Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Hepatic Stellate Cell Migration Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Norepinephrine Uptake	ATP-dependent Protein Folding Chaperone Protein Folding Chaperone Centrosome Unfolded Protein Binding BRCA2-MAGE-D1 Complex Mitotic Recombination-dependent Replication Fork Processing Denatured Protein Binding Protein Folding Nuclear Ubiquitin Ligase Complex Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Histone H3 Acetyltransferase Activity Cytoskeleton Establishment Of Protein Localization To Telomere Regulation Of Protein Stability ATP Hydrolysis Activity C3HC4-type RING Finger Domain Binding Protein Stabilization Death Receptor Agonist Activity ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Microtubule Nucleation Cellular Heat Acclimation Zona Pellucida Receptor Complex ScaRNA Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Histone H4 Acetyltransferase Activity Negative Regulation Of Inclusion Body Assembly Regulation Of Telomerase RNA Localization To Cajal Body Regulation Of Cellular Response To Stress Lateral Element Telomere Maintenance Via Recombination Regulation Of Mammary Gland Epithelial Cell Proliferation Inner Cell Mass Cell Proliferation Response To UV-C DNA Repair Complex Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Organelle Organization Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Centrosome Duplication Mitotic Recombination Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Unfolded Protein Inclusion Body Misfolded Protein Binding Regulation Of Microtubule Nucleation Positive Regulation Of Biosynthetic Process Regulation Of Inclusion Body Assembly
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