DPYSL4 and PTPRO

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		DPYSL4	PTPRO
Description		dihydropyrimidinase like 4	protein tyrosine phosphatase receptor type O
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane Membrane Apical Plasma Membrane Lateral Plasma Membrane Lamellipodium Axon Growth Cone Neuron Projection Dendritic Spine Extracellular Exosome Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Filamin Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Wnt-protein Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Pyrimidine Nucleobase Catabolic Process Nervous System Development	Cell Morphogenesis Monocyte Chemotaxis Regulation Of Glomerular Filtration Negative Regulation Of Glomerular Filtration Axon Guidance Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development Lamellipodium Assembly Glomerulus Development Slit Diaphragm Assembly Regulation Of Synapse Organization Podocyte Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Retinal Ganglion Cell Axon Guidance
Pathways		CRMPs in Sema3A signaling	Signaling by NTRK3 (TRKC)
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Cognitive function ( 22126837) General cognitive ability ( 29844566) Glomerular filtration rate (creatinine) ( 26831199) Homeostasis model assessment of insulin resistance ( 33381925) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Intelligence (MTAG) ( 29326435) Metamizole-induced agranulocytosis or neutropenia ( 33138277) Obstetric antiphospholipid syndrome ( 28424481) Temporal pole volume ( 31530798)
Interacting Genes		9 interacting genes: DPYSL5 PTPRO RBPMS SH3GL1 SH3GL2 SH3GL3 TRIM54 TRIP13 WEE2-AS1	10 interacting genes: ACTG1 APP DPPA4 DPYSL4 KIT PIM1 SH3GL1 SH3GL3 UFL1 YWHAZ
Entrez ID		10570	5800
HPRD ID		07463	02784
Ensembl ID		ENSG00000151640	ENSG00000151490
Uniprot IDs		O14531	Q16827
PDB IDs		5NKS	2G59 2GJT
Enriched GO Terms of Interacting Partners?		Glutamatergic Synapse Negative Regulation Of Cellular Component Organization Central Nervous System Development Presynapse Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Glomerular Filtration Negative Regulation Of Retinal Ganglion Cell Axon Guidance Filtration Diaphragm Assembly Slit Diaphragm Assembly Lipid Binding Signal Transduction Endocytosis Identical Protein Binding System Development Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Blood-brain Barrier Permeability Negative Regulation Of Clathrin-dependent Endocytosis Meiotic Recombination Checkpoint Signaling MRNA CDS Binding Pre-mRNA 5'-splice Site Binding Postsynaptic Endosome	Basal Body Patch Regulation Of Endocytosis Developmental Process Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Presynapse Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Myeloid Cell Development System Development Central Nervous System Development Regulation Of Long-term Neuronal Synaptic Plasticity Visual Behavior Regulation Of Immune Response Regulation Of Response To Calcium Ion Early Endosome Membrane Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Defense Response Defense Response To Bacterium Neuron Recognition Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Melanocyte Adhesion Stem Cell Factor Receptor Activity Positive Regulation Of Colon Smooth Muscle Contraction Negative Regulation Of Immune Response Negative Regulation Of TORC1 Signaling Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cardioblast Proliferation UFM1 Ligase Activity Cellular Response To Type II Interferon Erythrocyte Differentiation Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Regulation Of Defense Response Cellular Component Assembly Acetylcholine Receptor Activator Activity Regulation Of Immune System Process Regulation Of Cell Differentiation Regulation Of Developmental Process Positive Regulation Of Neuron Differentiation Lipoprotein Particle Positive Regulation Of Protein Import Phosphorylation Negative Regulation Of TOR Signaling
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