LAMTOR5 and MAF1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LAMTOR5	MAF1
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	MAF1 negative regulator of RNA polymerase III
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Late Endosome Membrane Protein-containing Complex Ragulator Complex FNIP-folliculin RagC/D GAP	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Axon Dendrite Perinuclear Region Of Cytoplasm Inhibitory Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity	RNA Polymerase III Core Binding RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Protein Binding GABA Receptor Binding
	Biological Process	Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Viral Genome Replication Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production TORC1 Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling	Negative Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Transcription By RNA Polymerase III
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS			Asthma ( 31959851 32296059) Serum metabolite concentrations in chronic kidney disease ( 33838163)
Interacting Genes		64 interacting genes: ACAA2 AKR1C2 ALB ANKRD46 ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLCC1 CLIC5 DBI DNAJA3 ECT2 EEF1A1 EIF3A EIF4B GAPDH GIT1 GIT2 GPRASP1 HEBP2 HSPA9 ITGB1 KEAP1 KIF1B KMT2E LRIF1 MAF1 MCPH1 MED12L MEOX2 MKLN1 MT2A MYF6 MYH3 MYOG NCOA6 PDK1 PEG10 PPARA RABIF RBP4 SERPINA1 SFPQ SHB SKP1 SMAD4 SNX5 TAF9 TBC1D4 TCAP TCF12 TGFB1 TOP2B TP53 TRIM55 TRIM63 UTP14A YTHDC1 ZBTB16 ZNF592	9 interacting genes: CCND3 CDKN2A CSNK2A1 CSNK2A2 DDIAS LAMTOR5 MTOR NUDT3 SUMO2
Entrez ID		10542	84232
HPRD ID		09773	14345
Ensembl ID		ENSG00000134248	ENSG00000179632
Uniprot IDs		A0A8Z5A536 O43504	Q9H063
PDB IDs		3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 5YK5 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB	3NR5
Enriched GO Terms of Interacting Partners?		Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Animal Organ Development Negative Regulation Of Glycolytic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Glucose Metabolic Process Muscle Organ Development Regulation Of Skeletal Muscle Tissue Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of ATP Metabolic Process Disordered Domain Specific Binding Cell Activation Centrosome Striated Muscle Tissue Development RNA Polymerase II Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Response To Muscle Activity Muscle Structure Development Muscle Tissue Morphogenesis Negative Regulation Of Growth Regulation Of MiRNA Transcription Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Small Molecule Metabolic Process Leukocyte Activation Positive Regulation Of RNA Metabolic Process Muscle Tissue Development Regulation Of Purine Nucleotide Metabolic Process Striated Muscle Atrophy Regulation Of Muscle Cell Differentiation Lymphocyte Activation Lymphocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of DNA-templated Transcription Hexose Metabolic Process Protein-containing Complex Binding Germ Cell Migration Regulation Of MiRNA Metabolic Process Anterior/posterior Pattern Specification Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Sarcomere Organization Regulation Of Striated Muscle Tissue Development Muscle Atrophy Heart Development Identical Protein Binding	Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Regulation Of Proteasomal Protein Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Catabolic Process Regulation Of Programmed Cell Death Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Catabolic Process PML Body Negative Regulation Of Apoptotic Process Apoptotic Process SUMO Transferase Activity Programmed Cell Death Cell Death Negative Regulation Of Programmed Cell Death RNA Decapping Regulation Of Protein Localization To Nucleus PcG Protein Complex Regulation Of Cell Cycle Regulation Of Cellular Response To Stress Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Protein Stabilization Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Protein Sumoylation Regulation Of Cell Cycle Process Autophagy Protein Destabilization Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Ligase Inhibitor Activity Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Protein Serine Kinase Activity Regulation Of Chromosome Separation Regulation Of Protein Stability
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