CLEC10A and CLN6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLEC10A	CLN6
Description		C-type lectin domain containing 10A	CLN6 transmembrane ER protein
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Early Endosome Membrane	Nucleolus Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Membrane Raft
	Molecular Function	Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Fucose Binding	Protein Binding Lysophosphatidic Acid Binding Protein Homodimerization Activity Sulfatide Binding
	Biological Process	Adaptive Immune Response Immune System Process Endocytosis Immune Response Innate Immune Response	Ganglioside Metabolic Process Lysosome Organization Lysosomal Lumen Acidification Visual Perception Cholesterol Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Glycosaminoglycan Metabolic Process Locomotion Involved In Locomotory Behavior Positive Regulation Of Proteolysis
Pathways		Dectin-2 family
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Liver enzyme levels (alkaline phosphatase) ( 33972514) Neurological blood protein biomarker levels ( 31320639)	Major depressive disorder ( 23377640) Restless legs syndrome ( 29029846)
Interacting Genes		26 interacting genes: ACSF2 ADIPOQ APOD BET1 C3orf52 CFTR CLN6 FMO3 FXYD6 GIMAP1 MALL NAPB PEX16 PRAF2 SEC22A SLC38A7 SMCO4 SNCA TMEM218 TNF TRARG1 TSPO UNC50 VSTM1 ZDHHC15 ZFPL1	26 interacting genes: ARL13B CD79A CISD2 CLDN7 CLEC10A CPLX4 CREB3L1 CYBC1 EBAG9 EVI2B FAM209A FNDC9 GJA8 GORAB KIR2DL3 LIME1 LMNA LRRC25 RIC3 SLC22A23 SLC30A4 STX1A TEX264 TMEM139 TMEM237 TMPRSS2
Entrez ID		10462	54982
HPRD ID		12076	05991
Ensembl ID		ENSG00000132514	ENSG00000128973
Uniprot IDs		J3KR22 Q8IUN9	A0A024R601 Q9NWW5
PDB IDs		6PUV 6PY1 6W12 6XIY
Enriched GO Terms of Interacting Partners?		Membrane Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Endoplasmic Reticulum Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Protein Localization To Membrane Regulation Of Lipid Metabolic Process Negative Regulation Of Secretion Cellular Response To Epinephrine Stimulus Intracellular Protein Localization Positive Regulation Of Monoatomic Ion Transport Response To Epinephrine Regulation Of Chemokine Production Negative Regulation Of Transport Axon Regeneration Establishment Of Protein Localization Regulation Of Oxidative Phosphorylation Regulation Of Smooth Muscle Cell Proliferation Lipid Metabolic Process Glucose Metabolic Process Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Cytokine Production Negative Regulation Of Lipoprotein Lipid Oxidation Neuron Projection Regeneration Regeneration Small Molecule Metabolic Process Regulation Of Hormone Secretion Response To Xenobiotic Stimulus Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Secretion By Cell Positive Regulation Of Transport Negative Regulation Of Secretion By Cell Positive Regulation Of Glial Cell Proliferation Regulation Of Small Molecule Metabolic Process Negative Regulation Of Corticosterone Secretion Negative Regulation Of Lipid Transport Chemical Homeostasis Response To Alcohol Positive Regulation Of Monoatomic Ion Transmembrane Transport Endoplasmic Reticulum Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Albendazole Monooxygenase Activity Response To Desipramine Regulation Of Aerobic Respiration Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity	Membrane B Cell Receptor Complex
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