MERTK and TNK2

Number of citations of the paper that reports this interaction (PubMedID 16288044)
0

Data Source:
HPRD (in vivo)

		MERTK	TNK2
Description		MER proto-oncogene, tyrosine kinase	tyrosine kinase non receptor 2
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Space Cytoplasm Plasma Membrane Membrane Receptor Complex	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Anchoring Junction Grb2-EGFR Complex Cytoophidium
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding WW Domain Binding Protein Serine Kinase Activity
	Biological Process	Natural Killer Cell Differentiation Negative Regulation Of Cytokine Production Protein Phosphorylation Phagocytosis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Spermatogenesis Nervous System Development Cell Migration Platelet Activation Secretion By Cell Substrate Adhesion-dependent Cell Spreading Apoptotic Cell Clearance Lymphocyte Activation Positive Regulation Of Phagocytosis Negative Regulation Of Lymphocyte Activation Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Retina Development In Camera-type Eye Vagina Development Neutrophil Clearance Negative Regulation Of Leukocyte Apoptotic Process	Endocytosis Signal Transduction Cell Surface Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-dependent Endocytosis
Pathways		Cell surface interactions at the vascular wall	Signaling by LTK
Drugs		2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol Fostamatinib	ATP Debromohymenialdisine Entrectinib Fostamatinib
Diseases		Retinitis pigmentosa (RP)
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Alanine aminotransferase levels ( 34315874 33547301) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874 33547301) Cluster headache ( 34184781) Coronary artery disease ( 33020668 29212778) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Hepatitis C induced liver fibrosis ( 22841784) Multiple sclerosis ( 21833088 31604244) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Systolic blood pressure ( 30224653)	Asthma ( 31959851) Bronchopulmonary dysplasia ( 23897914) Low density lipoprotein cholesterol levels ( 30498476) Total cholesterol levels ( 30498476)
Interacting Genes		11 interacting genes: BMPR2 DSCAM ERBB2 GAS6 GRB2 IKBKG LCOR LMO4 NEDD4L TNK2 VAV1	52 interacting genes: AKT1 AQP1 AR ARSL ATP5F1A BAG3 CDC42 CLTC CSPG4 CTTN CYSRT1 DPH2 EGFR FGFR1 FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NLA NPHP1 PDGFRB PIK3R1 PIK3R3 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SH2D1B SIAH1 SMURF1 SNX9 SOCS4 SRC SRSF5 UBC VTI1B WAS WWOX WWP2 YES1
Entrez ID		10461	10188
HPRD ID		05269	06104
Ensembl ID		ENSG00000153208	ENSG00000061938
Uniprot IDs		Q12866	A0A499FJ16 A0A5F9ZGX5 A0A5F9ZHJ2 A0A5F9ZHP4 A0A5F9ZI29 B3KXJ4 C9J1X3 Q07912
PDB IDs		2DBJ 2P0C 3BPR 3BRB 3TCP 4M3Q 4MH7 4MHA 5K0K 5K0X 5TC0 5TD2 5U6C 6MEP 7AAX 7AAY 7AAZ 7AB0 7AB1 7AB2 7AVX 7AVY 7AVZ 7AW0 7AW1 7AW2 7AW3 7AW4 7CQE 7DXL 7M5Z 7OAM 7OLS 7OLV 7OLX 7XHY 9BHI 9BHJ 9BHK	1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7 5ZXB 6VQM 7KP6 8FE9 8FZ3 8HMT 8Q5P 8THA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphorylation Grb2-EGFR Complex Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Growth Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Endocytosis Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Growth Cell Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Import Into Cell Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Activation Regulation Of Axon Extension Involved In Axon Guidance Cellular Developmental Process Schwann Cell Development Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Chemotaxis Intracellular Signaling Cassette Motor Neuron Axon Guidance Positive Regulation Of Developmental Growth Neuron Projection Development Regulation Of Metabolic Process Epidermal Growth Factor Receptor Binding Regulation Of Lymphocyte Activation Neuromuscular Junction Development Positive Regulation Of Axon Extension Regulation Of Chemotaxis Natural Killer Cell Mediated Cytotoxicity Protein Tyrosine Kinase Binding Growth Factor Binding Neuron Projection Guidance Axon Guidance Positive Regulation Of Protein Phosphorylation Natural Killer Cell Mediated Immunity T Cell Costimulation Positive Regulation Of Cellular Component Organization Regulation Of Growth Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Synapse Organization Regulation Of Kinase Activity Regulation Of Natural Killer Cell Mediated Cytotoxicity	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytosol Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Cell-cell Junction Ephrin Receptor Binding Signal Transduction Cell Migration Cell Motility Regulation Of Cell Projection Organization Intracellular Signal Transduction Regulation Of Signal Transduction Leukocyte Activation Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization T Cell Costimulation Actin Filament Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Peptidyl-tyrosine Phosphorylation Cell Activation Regulation Of Apoptotic Process Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization To Membrane Regulation Of Programmed Cell Death Regulation Of Actin Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Lymphocyte Activation Negative Regulation Of Apoptotic Process Regulation Of Actin Filament Organization Positive Regulation Of Locomotion Regulation Of Protein Localization To Plasma Membrane Plasma Membrane Protein Autophosphorylation Cell Differentiation Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Biological Quality Protein Kinase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Locomotion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?