TAB1 and IFT27

		TAB1	IFT27
Description		TGF-beta activated kinase 1 (MAP3K7) binding protein 1	intraflagellar transport 27
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endosome Membrane Membrane Protein-containing Complex	Golgi Membrane Nucleus Cytoplasm Golgi Apparatus Centrosome Cilium Intraciliary Transport Particle B Motile Cilium Sperm Flagellum Cell Projection Sperm Midpiece Sperm Principal Piece Ciliary Tip
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase P38 Binding Molecular Adaptor Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	In Utero Embryonic Development Heart Morphogenesis Cardiac Septum Development Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Lung Development Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Aorta Development Non-canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Coronary Vasculature Development CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Kidney Development Intracellular Protein Transport Smoothened Signaling Pathway Spermatogenesis Protein Transport Vesicle-mediated Transport Cell Differentiation Intraciliary Anterograde Transport Intraciliary Transport Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Cochlea Development
Pathways		NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	Intraflagellar transport Intraflagellar transport
Drugs		Manganese
Diseases
GWAS		Factor VIII levels ( 30586737) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 23128233) Intelligence (MTAG) ( 29326435) Schizophrenia ( 29483656) Serum alkaline phosphatase levels ( 33547301) Sleep duration (short sleep) ( 30846698) vWF levels ( 30586737) Waist circumference ( 28552196)
Interacting Genes		81 interacting genes: AATK ACAP3 APOA2 ARAP1 ASRGL1 BMPR1A C9orf78 CARD11 CASP6 CDK5RAP3 CFL1 CKB CORO1A CXCL16 DBN1 DVL2 EGFR EPRS1 ERBB4 FADD FN1 GIT1 HMGXB4 HNRNPR IFT27 IKBKG ITCH KDELR3 KIFC2 LAP3 LCMT1 LGALS7 LGALS7B LNX2 MAP3K1 MAP3K7 MAPK11 MAPK14 MAPKAPK5 MICAL1 MON1A MTG2 NR2C2 NXPH3 OGT PDCD6IP PHACTR3 PHC2 POLDIP2 POLR3D PPP1R7 PPP2CB PPP2R1A PRKAR1A PTPMT1 RBX1 ROR2 RPL10 RPLP1 SERPINA4 SMAD6 SMAD7 SMURF1 SNRNP35 TAB2 TAB3 TOM1 TRAF2 TRAF6 TRIM26 TRIP6 TRPC4AP TSSC4 UBC URB1 WDCP WTAP XIAP XPO7 YWHAG ZMYND11	3 interacting genes: GOLGA2 IFT25 TAB1
Entrez ID		10454	11020
HPRD ID		04012	11478
Ensembl ID		ENSG00000100324	ENSG00000100360
Uniprot IDs		A8K6K3 Q15750	Q9BW83
PDB IDs		2J4O 2POM 2POP 2YDS 2YIY 4AY5 4AY6 4GS6 4KA3 4L3P 4L52 4L53 4O91 5DIY 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5NZZ 5O90 5V5N 5VVU 7NTH 7NTI 8GW3 8XI8 9FPD
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction P38MAPK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Negative Regulation Of Intracellular Signal Transduction Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Signal Transduction Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytosol Intracellular Signaling Cassette Negative Regulation Of Signal Transduction MAPK Cascade Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Programmed Cell Death Cytoplasm Regulation Of Cytokine Production Regulation Of Protein Metabolic Process Positive Regulation Of Signaling Negative Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Apoptotic Process Activin Receptor Binding Positive Regulation Of Growth Positive Regulation Of Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Cell Communication Positive Regulation Of Proteolysis Regulation Of JNK Cascade Cellular Response To Growth Factor Stimulus Protein Polyubiquitination Endosome Membrane Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of T Cell Mediated Immunity Protein-containing Complex Protein Metabolic Process Regulation Of Necroptotic Process TORC1 Signaling Apoptotic Process Response To Virus Positive Regulation Of Macromolecule Metabolic Process	Positive Regulation Of Protein Glycosylation Cellular Localization Protein Transport Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Transport Lung Development Regulation Of Protein Glycosylation Intracellular Protein Localization Golgi Disassembly Mitogen-activated Protein Kinase P38 Binding Positive Regulation Of CGAS/STING Signaling Pathway Importin-alpha Family Protein Binding Golgi Ribbon Formation Golgi Cis Cisterna Asymmetric Cell Division Kinase Activator Activity Left/right Axis Specification Meiotic Spindle Assembly Positive Regulation Of Glycoprotein Biosynthetic Process Intraciliary Transport Particle B Intraciliary Anterograde Transport Positive Regulation Of Glycoprotein Metabolic Process Meiotic Spindle Organization Coronary Vasculature Development Negative Regulation Of Protein Binding Microtubule Nucleation Organelle Assembly CGAS/STING Signaling Pathway Protein Exit From Endoplasmic Reticulum Non-canonical NF-kappaB Signal Transduction Aorta Development Regulation Of Glycoprotein Biosynthetic Process COPII-coated ER To Golgi Transport Vesicle Regulation Of Protein Binding Centrosome Cycle Cis-Golgi Network Mitotic Spindle Assembly Microtubule-based Process Artery Development Cardiac Septum Development Intraciliary Transport Ciliary Tip Syntaxin Binding Heart Morphogenesis Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Protein Homotetramerization
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