ARIH2 and ITIH1

		ARIH2	ITIH1
Description		ariadne RBR E3 ubiquitin protein ligase 2	inter-alpha-trypsin inhibitor heavy chain 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex	Extracellular Region Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Serine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding Hyaluronic Acid Binding Carbohydrate Binding Peptidase Inhibitor Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Developmental Cell Growth Defense Response To Virus Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion	Hyaluronan Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)	A body shape index ( 34021172) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 34002096 33263727 31043756 19416921) Body mass index ( 25673413) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) Glaucoma (primary open-angle) ( 25173105) Osteoarthritis (hip) ( 30374069) Pulse pressure ( 30578418) Schizophrenia ( 29483656 25056061 23974872) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		59 interacting genes: APOBEC3C APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST DSCAM EEF1A1 EEF1G EIF4E2 EML4 ENSA IL4R ITIH1 KAT5 KCNQ2 MEOX2 NEDD8 OGT PAX6 PHF7 PPP2R1A PTN RBX1 REL RHEB RHOA RNF7 RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 USP2-AS1 UTP14A WDR91	8 interacting genes: ARF4 ARIH2 CALR HSP90AA1 PHAX PIK3CA RBM15B SOX4
Entrez ID		10425	3697
HPRD ID		09286	00927
Ensembl ID		ENSG00000177479	ENSG00000055957
Uniprot IDs		O95376 Q53ET9 Q6IBL8	B7Z8B6 P19827
PDB IDs		7OD1 7ONI	6FPY 6FPZ
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Protein Monoubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Cytosol Transferase Activity Macromolecule Metabolic Process Protein Modification Process Macromolecule Catabolic Process Protein Metabolic Process Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Proteolysis TOR Signaling Catabolic Process Protein Neddylation ISG15-protein Conjugation DNA Cytosine Deamination TORC1 Signaling Nucleoplasm Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Cytidine To Uridine Editing Cytidine Deaminase Activity DNA Deamination Negative Regulation Of Neuroblast Proliferation Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Neuroblast Proliferation Regulation Of Neural Precursor Cell Proliferation Regulation Of Post-translational Protein Modification Base Conversion Or Substitution Editing Negative Regulation Of Gene Expression Regulation Of TORC1 Signaling Cellular Response To Nutrient Levels Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination UBC13-MMS2 Complex Regulation Of Protein Metabolic Process Ubiquitin-like Protein Transferase Activity Ubiquitin Ligase Complex	Regulation Of Cell Projection Assembly Regulation Of Apoptotic Process Intracellular Transport Nuclear Export Nuclear Transport Nucleocytoplasmic Transport Protein Stabilization Endocytic Vesicle Lumen MRNA Binding Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Lamellipodium Assembly Regulation Of Programmed Cell Death Cellular Localization Establishment Of Localization In Cell Regulation Of Lamellipodium Organization Protein Folding Chaperone Positive Regulation Of Establishment Of Protein Localization Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Glucose Stimulus CTP Binding DATP Binding Regulation Of Protein Localization Cellular Response To Virus Regulation Of Protein Stability Cellular Response To Carbohydrate Stimulus ERBB Signaling Pathway Response To Virus RNA Export From Nucleus Striated Muscle Contraction Regulation Of Gene Expression Positive Regulation Of Immune System Process Intracellular Glucose Homeostasis Regulation Of Macromolecule Biosynthetic Process Protein Transport Phospholipase D Activator Activity Positive Regulation Of Protein Localization Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Unfolded Protein Binding Regulation Of Organelle Organization Response To Biphenyl Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Rho GDP-dissociation Inhibitor Binding Response To Butyrate Cellular Response To Hydrostatic Pressure Intracellular Chemical Homeostasis Regulation Of Establishment Of Protein Localization Response To Glucose
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