MAEA and GID4

Number of citations of the paper that reports this interaction (PubMedID 27173435)
70

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MAEA	GID4
Description		macrophage erythroblast attacher, E3 ubiquitin ligase	GID complex subunit 4 homolog
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Nuclear Matrix GID Complex	Ubiquitin Ligase Complex Cytosol
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin Protein Ligase Activity
	Biological Process	Cytoskeleton Organization Cell Adhesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Myeloid Cell Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Erythrocyte Maturation Erythrocyte Development Enucleate Erythrocyte Development Cell Division	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Regulation of pyruvate metabolism	Regulation of pyruvate metabolism
Drugs		Tetrachlorodecaoxide
Diseases
GWAS		Fasting glucose ( 34059833) Obesity-related traits ( 23251661) Pulse pressure ( 30224653) Type 2 diabetes ( 22158537 23945395 26818947 28869590 30297969 30718926 32499647)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Myocardial infarction ( 33532862) Schizophrenia ( 25056061 29483656) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: GID4 GSK3A MYOC UBE2D3 UBE2H UBE2R2	6 interacting genes: DRC3 ELAC2 FAM106A MAEA UBE2H ZMYND19
Entrez ID		10296	79018
HPRD ID		08427	12683
Ensembl ID		ENSG00000090316	ENSG00000141034
Uniprot IDs		B3KRN7 B4DJP8 B4DQT1 B4DVN3 D6RIB6 Q7L5Y9	B3KXL6 K4DI96 Q8IVV7
PDB IDs		8PJN	6CCR 6CCT 6CCU 6CD8 6CD9 6CDC 6CDG 6WZX 6WZZ 7NSC 7Q4Y 7Q50 7SLZ 7U3E 7U3F 7U3G 7U3H 7U3I 7U3J 7U3K 7U3L 8V1P
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteolysis Involved In Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein K48-linked Ubiquitination Proteolysis Proteasomal Protein Catabolic Process Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Ubiquitin-protein Transferase Activity Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Protein Polyubiquitination Protein K11-linked Ubiquitination Catabolic Process Regulation Of Protein Targeting To Mitochondrion Protein Monoubiquitination Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of UDP-glucose Catabolic Process Skeletal Muscle Hypertrophy ATP Binding Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Cell-substrate Adhesion Protein Ubiquitination Protein Modification By Small Protein Conjugation Transferase Activity Nucleotide Binding Regulation Of Glycogen (starch) Synthase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Clustering Of Voltage-gated Sodium Channels Autosome Genomic Imprinting Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Post-translational Protein Modification Regulation Of Cell-substrate Adhesion Cellular Response To Interleukin-3 Myosin Light Chain Binding Skeletal Muscle Adaptation Proximal Dendrite Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Positive Regulation Of Mitochondrial Depolarization Wnt Signaling Pathway	Enucleate Erythrocyte Development TRNA-specific Ribonuclease Activity 3'-tRNA Processing Endoribonuclease Activity Mitochondrial TRNA 3'-end Processing Actomyosin Contractile Ring GID Complex Mitochondrial RNA 3'-end Processing Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity TRNA Decay TRNA 3'-end Processing Mitochondrial TRNA Processing
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