SPEG and PNKD

		SPEG	PNKD
Description		striated muscle enriched protein kinase	PNKD metallo-beta-lactamase domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Presynaptic Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Hydroxyacylglutathione Hydrolase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Muscle Organ Development Negative Regulation Of Cell Population Proliferation Cell Differentiation Muscle Cell Differentiation	Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Dopamine Metabolic Process Negative Regulation Of Neurotransmitter Secretion Neuromuscular Process Controlling Posture
Pathways
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS		Age at first sexual intercourse ( 34211149) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Resting heart rate ( 27798624 29769521)	Appendicular lean mass ( 33097823) Colorectal cancer ( 28960316) Colorectal cancer or advanced adenoma ( 30510241) Glycated hemoglobin levels ( 34059833) Granulocyte count ( 27863252) Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Liver enzyme levels (alkaline phosphatase) ( 33972514) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30578418) Triglyceride levels ( 32203549) White blood cell count ( 27863252)
Interacting Genes		6 interacting genes: APP HSF2BP MEOX2 PICK1 PNKD PRMT1	10 interacting genes: APP CNPPD1 ENO3 GMPPA KCTD9 KLHL20 MAGEA11 MYL12B SPEG UBC
Entrez ID		10290	25953
HPRD ID		10653	11369
Ensembl ID		ENSG00000072195	ENSG00000127838
Uniprot IDs		B9ZVR7 Q15772	Q8N490
PDB IDs		1U2H
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Neuron Projection Organization Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of JNK Cascade Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Trans-Golgi Network Membrane Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus G Protein-coupled Receptor Binding Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Growth Factor Receptor Binding Main Axon Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Receptor Internalization Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Glial Cell Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Protein-arginine Omega-N Monomethyltransferase Activity Striated Muscle Tissue Development Cellular Response To Starvation N-methyltransferase Activity Histone H4R3 Methyltransferase Activity GATOR1 Complex Binding Muscle Tissue Development Positive Regulation Of Hemoglobin Biosynthetic Process Peptidyl-arginine Methylation Somite Specification Membrane Curvature Sensor Activity Hydroxyacylglutathione Hydrolase Activity
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