CDKN1A and ACTB

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		CDKN1A	ACTB
Description		cyclin dependent kinase inhibitor 1A	actin beta
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Body Protein-containing Complex PCNA-p21 Complex	Kinetochore Chromatin Nucleosome Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Cell-cell Junction Adherens Junction Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex Lamellipodium Axon Cortical Cytoskeleton Vesicle Protein-containing Complex Brahma Complex NuA4 Histone Acetyltransferase Complex Cytoplasmic Ribonucleoprotein Granule Apical Junction Complex Calyx Of Held Synapse Extracellular Exosome Tight Junction NpBAF Complex NBAF Complex Blood Microparticle Dense Body Schaffer Collateral - CA1 Synapse Presynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse BBAF Complex GBAF Complex Ribonucleoprotein Complex
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Metal Ion Binding Protein Serine/threonine Kinase Binding Protein Sequestering Activity Molecular Function Activator Activity Molecular Function Inhibitor Activity	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Kinesin Binding Protein Kinase Binding Nitric-oxide Synthase Regulator Activity Tat Protein Binding Nucleosomal DNA Binding Identical Protein Binding Tau Protein Binding Nitric-oxide Synthase Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Transporter Regulator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Protein Import Into Nucleus DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epidermis Development Response To UV Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Keratinocyte Differentiation Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of B Cell Proliferation Mitotic G1 DNA Damage Checkpoint Signaling Cellular Response To Amino Acid Starvation Wound Healing Tissue Regeneration Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Programmed Cell Death Keratinocyte Proliferation Positive Regulation Of DNA Replication Positive Regulation Of Protein Kinase Activity Negative Regulation Of Growth Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Import Into Nucleus Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To UV-B Signal Transduction By P53 Class Mediator Cellular Senescence Replicative Senescence Stress-induced Premature Senescence Oncogene-induced Cell Senescence Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Morphogenesis Of A Polarized Epithelium Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Axonogenesis Positive Regulation Of Cell Population Proliferation Substantia Nigra Development Regulation Of Mitotic Metaphase/anaphase Transition Adherens Junction Assembly Maintenance Of Blood-brain Barrier Regulation Of Apoptotic Process Apical Protein Localization Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Cell Motility Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Regulation Of Cell Cycle Regulation Of G0 To G1 Transition Platelet Aggregation Protein Localization To Adherens Junction Cellular Response To Cytochalasin B Postsynaptic Actin Cytoskeleton Organization Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Stem Cell Population Maintenance Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Neddylation Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation HATs acetylate histones Prefoldin mediated transfer of substrate to CCT/TriC Folding of actin by CCT/TriC EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOF GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs		Valproic acid Arsenic trioxide	Quercetin Phenethyl Isothiocyanate
Diseases		Cervical cancer	Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Abdominal aortic aneurysm ( 32981348) Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874 33547301) Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 30529582 31826910 22634755) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 20062063) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma (primary open-angle) ( 29891935) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) JT interval ( 29874175) Left ventricle wall thickness ( 33495596) Left ventricular fractional shortening ( 28394258) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) QRS complex (Cornell) ( 27659466) QRS duration ( 31251759 31217584 30679814 27659466 27577874 25035420 21076409) Triglyceride levels ( 32203549) Triglycerides ( 27036123)	Global electrical heterogeneity phenotypes ( 29622589) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Relative hand skill in reading disability ( 24068947) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		209 interacting genes: A1BG A2M ABL1 ACTB ACTL6B ADAMTS10 AKT1 AKT2 ALAS1 ANGPT2 APLP1 APP ATP5F1B ATP6V1A ATXN3 BAD BAG6 BCCIP CASP3 CCDC85B CCN3 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC45 CDC5L CDC6 CDC7 CDK1 CDK12 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHEK2 CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB CZIB DAPK3 DCAF11 DDAH2 DEAF1 DOCK7 DTL DYNC1I1 EEF1A1 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FHL3 FLAD1 FNDC11 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB5 GOLGA2 H1-5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HMGXB3 HNRNPK HOOK2 HOXD8 HPD IKBKG IKZF3 INCA1 ING5 INPP5K KIFC3 KLHL23 KMT2B KRT31 KRTAP3-1 LATS2 LRIF1 LRP2BP LRR1 LZTS2 MAP3K5 MAPK8 MCM10 MED31 MEOX2 MSH2 MTUS2 NFYA NGFR NKD2 NMRK2 NPRL2 NR1H2 NRBP1 NSUN2 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 POLD2 PPM1D PRKACA PRKAR1B PRKN PSMA3 PSMC2 PTK7 QARS1 RAB1A RACK1 RAI1 RANBP9 RB1 RBBP4 RBM48 REL RNF144B RPL18 RPL35 RPS2 RRM2B S100A8 SCML2 SDF4 SET SETDB1 SHISA6 SIPA1 SKP1 SLC25A11 SP110 SPRED1 STAT3 STAT5B STUB1 SUMO3 TAF5L TCF4 TEX11 TFIP11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TNKS TRAF1 TRIM21 TRIM3 TRIM54 TRIM71 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBE2D1 UNC119 USHBP1 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431	163 interacting genes: A2M ABLIM1 ABRA ACD ACTC1 ACTG1 ALOX5 ANXA7 AQP2 AR ARPC1B ATF7IP BBS4 BCL2L1 CAP1 CAPZA1 CCN2 CCT2 CCT4 CCT5 CCT8 CDC37 CDK5R2 CDKN1A CDKN2A CFL1 CFL2 CLIC4 CLIC6 CLNS1A CNN2 CORO1A CORO7 COTL1 CPNE1 CPNE2 CPNE4 CREBBP CSNK1A1 CSNK2B DMTN DNASE1 DSCR9 DSTN DUSP19 DYNLL1 EEF1A1 EHHADH EMD ERG EZR FABP4 FHL3 FLII FXR1 GAPDH GNA12 GSN H2AX HCK HIP1R HMMR HNRNPAB HNRNPD HNRNPU HSD17B4 HSPB2 HTR6 KHDRBS1 LASP1 LCOR LGALS13 LINC01554 LINC02582 LMNA LMOD1 LRRK2 LYN MAP1B MAP2 MAPT MRGBP MTNR1A MX1 MYO18B MYO1E MYOC NCALD NCF1 NDEL1 NEBL NOS2 NRAP NSMAF NT5E NTAQ1 OGT P2RX7 PCYT1A PDIA2 PDLIM5 PFDN1 PFDN4 PFN1 PFN2 PHACTR4 PLD1 PLD2 PLG POLR2A POT1 PRKCD PROSER2 PTN PTPRF RAB4A RAC1 RAC2 RALA RCC1 RPL10A S100A11 SAMHD1 SCN10A SHBG SMAD3 SMAD9 SMARCA4 SMN1 SPTAN1 SPTB SPTBN2 SRPK2 SSH1 SSH2 SSH3 STX4 SUMO2 SYNJ2BP TANC1 TCF12 TGM2 TINF2 TK1 TMSB4X TMSB4XP1 TMSB4XP4 TNNI2 TPM1 TPM2 TPM3 TRIM15 TSHR TTR UBC UBE2I UBE3A VHL VSNL1 WASF1 WASF2 WASF3 XPO6
Entrez ID		1026	60
HPRD ID		00298	00032
Ensembl ID		ENSG00000124762	ENSG00000075624
Uniprot IDs		P38936	P60709 Q1KLZ0
PDB IDs		1AXC 2ZVV 2ZVW 4RJF 5E0U 6CBI 6CEJ 6CIV 6CIX 6P8H 7KQ0 7KQ1 8GJF	3BYH 3D2U 3J82 3LUE 6ANU 6ICT 6ICV 6LTJ 6MBJ 6MBK 6MBL 6NBW 6OX0 6OX1 6OX2 6OX3 6OX4 6OX5 6V62 6V63 6WK1 6WK2 7AS4 7P1H 7QJ6 7QJ9 7VDV 7W28 7W29 7Y8R 7ZTC 7ZTD 8COG 8DNH 8IB8 8OI8 8OID 8QR1 8RTT 8RTY 8RU2 8RX1 8UAU 8VRD 8VRJ 8VRK 8X15 8X19 8X1C 8XVG 8XVT 9B2Z 9C57 9C62 9C6N 9FJM
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Regulation Of Primary Metabolic Process Cytoplasm G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cyclin Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Cytosol Regulation Of Programmed Cell Death Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Division Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Signal Transduction Cellular Response To Stress Negative Regulation Of Intracellular Signal Transduction Protein Binding Regulation Of Macromolecule Biosynthetic Process Protein Kinase Binding Regulation Of DNA-templated Transcription Negative Regulation Of Cell Cycle Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Biosynthetic Process Positive Regulation Of Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Fibroblast Proliferation Negative Regulation Of Signaling Negative Regulation Of Cell Communication	Actin Binding Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Organelle Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Negative Regulation Of Supramolecular Fiber Organization Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Actin Filament-based Process Actin Filament Binding Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Actin Filament Organization Negative Regulation Of Cytoskeleton Organization Cytoskeleton Negative Regulation Of Actin Filament Polymerization Cytoplasm Negative Regulation Of Cellular Component Organization Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Organelle Organization Actin Cytoskeleton Regulation Of Biological Quality Negative Regulation Of Protein-containing Complex Assembly Extracellular Exosome Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cortical Actin Cytoskeleton Regulation Of Actin Filament Depolymerization Actin Filament Organelle Organization Glutamatergic Synapse Positive Regulation Of Cellular Component Organization Modification Of Postsynaptic Actin Cytoskeleton Cytosol Regulation Of Protein Localization Regulation Of Protein Depolymerization Negative Regulation Of Actin Filament Depolymerization Focal Adhesion Regulation Of Telomere Maintenance Via Telomerase Modification Of Postsynaptic Structure Actin Filament Capping Postsynapse Modification Of Synaptic Structure Regulation Of Cellular Localization
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