CDK9 and CDK5R1

Number of citations of the paper that reports this interaction (PubMedID 36736316)
80

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		CDK9	CDK5R1
Description		cyclin dependent kinase 9	cyclin dependent kinase 5 regulatory subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Membrane PML Body Cytoplasmic Ribonucleoprotein Granule P-TEFb Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Axon Dendrite Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Contractile Muscle Fiber Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA Binding Chromatin Binding Transcription Elongation Factor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity SnRNA Binding Protein Kinase Binding 7SK SnRNA Binding Protein Serine Kinase Activity	Protease Binding Actin Binding Protein Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Protein Kinase Binding Protein Kinase Activator Activity Ionotropic Glutamate Receptor Binding Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Beta-tubulin Binding Actin Filament Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	DNA Repair Regulation Of DNA Repair Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Protein Phosphorylation DNA Damage Response Regulation Of Mitotic Cell Cycle Cell Population Proliferation Replication Fork Processing Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Activation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Cell Differentiation Nucleus Localization Regulation Of Cell Cycle Cellular Response To Cytokine Stimulus Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Protein Localization To Chromatin Transcription Elongation-coupled Chromatin Remodeling Transcription Pausing By RNA Polymerase II	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization Neuron Migration Neuron Cell-cell Adhesion G Protein-coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Cerebral Cortex Radially Oriented Cell Migration Layer Formation In Cerebral Cortex Neuron Differentiation Positive Regulation Of Microtubule Polymerization Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of MHC Class II Biosynthetic Process Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis G1 To G0 Transition Involved In Cell Differentiation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression	CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription NGF-stimulated transcription Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes
Drugs		Alvocidib Seliciclib Trilaciclib Zotiraciclib	Indirubin-3'-monoxime 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS		Body mass index ( 26426971)
Interacting Genes		60 interacting genes: ACTL6A AFF4 AR BCL10 CASK CCNK CCNT1 CCNT2 CDC34 CDC7 CDK5R1 CEBPA CTDP1 CTDSPL CUL1 DHX30 EAF1 EEF1D FBXO25 GRN GTF2F1 H2BC21 HEXIM1 HEXIM2 HLTF HSPA1A HTATSF1 IL6ST LBX2 MBP MDFIC MED21 MYBL2 NBN NFKB1 NR2E3 OGT PIN1 POLR2A RB1 RCHY1 RELA RMND5B RN7SK SERPINH1 SKP1 SKP2 SMAD1 SMAD2 SMAD3 STAT3 STK36 STUB1 SUPT5H TAF7 TARBP2 TP53 TRAF2 UBE2A ZMYM6	37 interacting genes: ACTN1 AMPH APP BCL2L13 BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 FEM1B FEM1C HNF1B HSP90AA1 KRT40 KRTAP10-3 LMTK2 MAPT MTUS2 NEDD4 NES NOTCH2NLA ODF1 PAK1 SEPTIN5 SET SIAH1 STXBP1 SUZ12 TSC22D4 TTBK1
Entrez ID		1025	8851
HPRD ID		16016	04586
Ensembl ID		ENSG00000136807	ENSG00000176749
Uniprot IDs		P50750	Q15078 Q8N619
PDB IDs		3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH 6W9E 6Z45 7NWK 8I0L 8K5R	1H4L 1UNG 1UNH 1UNL 3O0G 6LDP 7CNG 7VDP 7VDQ 7VDR 7VDS
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Protein Modification Process Transcription Regulator Complex Positive Regulation Of MiRNA Metabolic Process RNA Metabolic Process Cyclin/CDK Positive Transcription Elongation Factor Complex 7SK SnRNA Binding Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of RNA Metabolic Process Protein-containing Complex Negative Regulation Of DNA-templated Transcription Positive Regulation Of MiRNA Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Intracellular Signal Transduction	Regulation Of Apoptotic Process Cytoplasm Developmental Process Cytosol Regulation Of Programmed Cell Death Positive Regulation Of Protein Polymerization Receptor Metabolic Process Acetylcholine Receptor Activator Activity Protein Kinase Binding Neurofibrillary Tangle Assembly Neuron Projection Development Protein Serine Kinase Activity Receptor Catabolic Process Developmental Growth Involved In Morphogenesis Apoptotic Process Regulation Of Neuron Apoptotic Process Regulation Of Developmental Process Perinuclear Region Of Cytoplasm Regulation Of Protein Localization Programmed Cell Death Cell Death Protein Serine/threonine Kinase Activity Establishment Of Organelle Localization Calpain Complex Cyclin-dependent Protein Serine/threonine Kinase Activity Amyloid Fibril Formation Cellular Developmental Process Regulation Of Neurotransmitter Secretion Main Axon Vesicle-mediated Transport In Synapse Positive Regulation Of Microtubule Polymerization Dendrite Organelle Localization Cell Differentiation Establishment Of Localization In Cell Regulation Of Cell Differentiation Synaptic Vesicle Transport NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Cell Projection Organization Establishment Of Vesicle Localization Synaptic Vesicle Endocytosis Protein Kinase Activity Neuron Apoptotic Process Neuronal Cell Body Presynaptic Endocytosis Tau Protein Binding Oligodendrocyte Differentiation Developmental Cell Growth
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