PLIN3 and M6PR

Number of citations of the paper that reports this interaction (PubMedID 10829017)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, two hybrid)

		PLIN3	M6PR
Description		perilipin 3	mannose-6-phosphate receptor, cation dependent
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Golgi Apparatus Lipid Droplet Cytosol Endosome Membrane Membrane Transport Vesicle	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Endomembrane System Membrane Transport Vesicle Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Cadherin Binding	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Protein Transporter Activity Retromer Complex Binding
	Biological Process	Positive Regulation Of Triglyceride Storage Vesicle-mediated Transport Lipid Storage Cellular Response To Glucose Starvation Lipid Droplet Disassembly	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes Glycosphingolipid Catabolic Process
Pathways		Triglyceride catabolism Retrograde transport at the Trans-Golgi-Network Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy RHOBTB3 ATPase cycle	Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Glycosphingolipid catabolism
Drugs		Idursulfase Galsulfase	Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
Diseases
GWAS		Basal cell carcinoma ( 27539887) Lung cancer in ever smokers ( 28604730) Visceral fat ( 30942860)	Sjögren's syndrome ( 28076899) Total cholesterol levels ( 30275531) Type 1 diabetes ( 34127860)
Interacting Genes		34 interacting genes: ABHD4 ABHD5 APP CCNC CEBPA CHMP4B CMTM5 CPD CYBC1 GAD2 HSD17B13 IGF2R LNPK M6PR MAX MIEF1 MYG1 PBX3 PIAS3 PTPN9 RAB9A SFT2D2 SMAD2 SNX1 SNX2 SPART SYNGR1 SYNGR3 SYP TARS2 TBC1D13 TBPL1 TMEM14C TUBB4A	13 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4 TMPRSS15
Entrez ID		10226	4074
HPRD ID		04080	01106
Ensembl ID		ENSG00000105355	ENSG00000003056
Uniprot IDs		A0A140VJN8 O60664	F5GX30 P20645
PDB IDs			1JUQ
Enriched GO Terms of Interacting Partners?		Collateral Sprouting In Absence Of Injury Insulin Receptor Binding Regulation Of Long-term Neuronal Synaptic Plasticity Vesicle-mediated Transport Identical Protein Binding Retromer, Tubulation Complex Leptin Receptor Binding Lipid Droplet Trans-Golgi Network Membrane Lamellipodium Morphogenesis Regulation Of Neuronal Synaptic Plasticity Endocytosis Nuclear Envelope Lumen Retromer Complex Binding Transferrin Receptor Binding Regulation Of Synaptic Vesicle Priming Lysophosphatidic Acid Acyltransferase Activity Intracellular Transport Receptor-mediated Endocytosis Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Membrane Organization Collateral Sprouting Early Endosome To Golgi Transport Neuromuscular Junction Endosome Establishment Of Protein Localization Neuron Projection Terminus Regulation Of Neurotransmitter Uptake Retromer Complex Protein Transport Retrograde Transport, Endosome To Golgi Midbody Abscission Transport Vesicle Cytoplasmic Vesicle Import Into Cell Mitotic Cytokinetic Process	Endosome Membrane Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Vesicle-mediated Transport To The Plasma Membrane Endosome Trans-Golgi Network Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Macrophage Activation Golgi Vesicle Transport Small GTPase Binding Leading Edge Cell Differentiation Protein Localization To Membrane Cellular Response To Anisomycin Juxtaglomerular Apparatus Development Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Triglyceride Storage
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