ACTR2 and IQGAP2

Number of citations of the paper that reports this interaction (PubMedID 12515716)
0

Data Source:
HPRD (in vivo)

		ACTR2	IQGAP2
Description		actin related protein 2	IQ motif containing GTPase activating protein 2
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Actin Cap Azurophil Granule Lumen Site Of Double-strand Break Cell Projection Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol Microtubule Plasma Membrane Microvillus Cell Cortex Cell Surface Actin Cytoskeleton Lamellipodium Filopodium Secretory Granule Membrane Cell Leading Edge Extracellular Exosome Plasma Membrane Bounded Cell Projection
	Molecular Function	Nucleotide Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding	Actin Binding GTPase Inhibitor Activity GTPase Activator Activity Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Small GTPase Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cytosolic Transport Actin Cytoskeleton Organization Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Meiotic Cell Cycle Spindle Localization Cilium Assembly Cellular Response To Type II Interferon Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Signal Transduction Regulation Of Actin Cytoskeleton Organization Arp2/3 Complex-mediated Actin Nucleation Thrombin-activated Receptor Signaling Pathway Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	RHO GTPases activate IQGAPs Neutrophil degranulation CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Calcific aortic valve stenosis ( 32141789) Coronary artery disease ( 29212778 33020668) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Metabolite levels ( 23823483)	A body shape index ( 34021172) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hearing impairment ( 20068591) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Late-onset Alzheimer's disease ( 27770636) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Phenylephrine infusion rate during anesthesia ( 31455332) Platelet count ( 32888494 27863252) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		20 interacting genes: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 CEBPA ELF5 ERCC6 FCGR2A FILNC1 HCLS1 IQGAP2 LINC00632 PLK4 SHARPIN WAS WASF1 WASF2 WASL	6 interacting genes: ACTR2 ALG8 CALM1 CDC42 RAC1 RHOG
Entrez ID		10097	10788
HPRD ID		05023	09253
Ensembl ID		ENSG00000138071	ENSG00000145703
Uniprot IDs		P61160	B7Z7U6 B7Z7X2 F5H7S7 Q13576 Q59HA3
PDB IDs		6UHC 6YW6 6YW7 8P94	3IEZ 4EZA 5CJP
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Actin Cytoskeleton Arp2/3 Complex-mediated Actin Nucleation Supramolecular Fiber Organization Actin Nucleation Actin Binding Arp2/3 Protein Complex Lamellipodium Actin Filament Polymerization Actin Filament Binding Actin Polymerization Or Depolymerization Arp2/3 Complex Binding Actin Filament-based Movement Regulation Of Cytoskeleton Organization Cytoskeleton Protein Polymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Actin Filament-based Process Site Of Double-strand Break Structural Constituent Of Cytoskeleton Regulation Of Actin Filament Organization Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization SCAR Complex Positive Regulation Of Actin Nucleation Focal Adhesion Trophoblast Giant Cell Differentiation Regulation Of Cell Projection Assembly Positive Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Regulation Of Organelle Organization SH3 Domain Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Regulatory Subunit Binding Rac Protein Signal Transduction Protein Kinase A Binding GTPase Regulator Activity	Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Lamellipodium Assembly Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Organization Actin Filament Organization Cellular Response To Type II Interferon G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Actin Cytoskeleton Organization Response To Type II Interferon Actin Filament-based Process Thioesterase Binding Focal Adhesion Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Protein Kinase Binding Supramolecular Fiber Organization Regulation Of Postsynapse Organization Cell Projection GTP-dependent Protein Binding Cytoskeleton Regulation Of Plasma Membrane Bounded Cell Projection Organization Rac Protein Signal Transduction Regulation Of Cell Projection Organization Regulation Of Ruffle Assembly Phagocytosis, Engulfment Postsynapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Postsynapse Assembly Substantia Nigra Development Cortical Cytoskeleton Organization Regulation Of Synapse Organization Membrane Invagination GTPase Activity Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Cytoskeleton Organization Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Endoplasmic Reticulum Membrane GTP Binding Cell Projection Assembly Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Projection Organization Positive Regulation Of Actin Filament Bundle Assembly Neural Nucleus Development Regulation Of Actin Filament-based Process
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