ARPC3 and PRMT1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARPC3	PRMT1
Description		actin related protein 2/3 complex subunit 3	protein arginine methyltransferase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Cell Leading Edge Filamentous Actin Site Of Double-strand Break Cell Projection Growth Cone Leading Edge Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Methylosome
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	RNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity Methyl-CpG Binding Protein-arginine N-methyltransferase Activity Transferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Histone H4R3 Methyltransferase Activity Mitogen-activated Protein Kinase P38 Binding GATOR1 Complex Binding Histone H4 Methyltransferase Activity S-adenosyl-L-methionine Binding
	Biological Process	Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Actin Polymerization-dependent Cell Motility Regulation Of Synaptic Vesicle Endocytosis Cellular Response To Nerve Growth Factor Stimulus	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation DNA Damage Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation RNA Splicing Negative Regulation Of Translation Peptidyl-arginine Methylation Viral Protein Processing BMP Signaling Pathway Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Neuron Projection Development Cellular Response To Nutrient Levels Methylation Cellular Response To Amino Acid Starvation TORC1 Signaling Positive Regulation Of Erythrocyte Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Negative Regulation Of Translational Initiation Negative Regulation Of JNK Cascade Positive Regulation Of Hemoglobin Biosynthetic Process Cardiac Muscle Tissue Development Protein Homooligomerization Cellular Response To Methionine Protein Localization To Lysosome Membraneless Organelle Assembly Positive Regulation Of P38MAPK Cascade Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	RMTs methylate histone arginines TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Extra-nuclear estrogen signaling Estrogen-dependent gene expression Maturation of nucleoprotein
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	S-adenosyl-L-homocysteine
Diseases
GWAS		Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)	Schizophrenia ( 29483656)
Interacting Genes		33 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CEBPA CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SRPK2 SYBU TARS3 THNSL2 WAS WASF2 WASHC4 WASL ZNF576	167 interacting genes: AR ARPC3 ASH2L AXIN1 BRCA1 BTG1 BTG2 C4orf17 CAPRIN1 CDC37 CEBPA CEP162 CIRBP CNOT8 COIL DAXX DCAF16 DCAF8 DHX9 EP300 ESR1 EWSR1 FAM83D FAM9A FBL FBXL17 FBXO7 FGF2 FLII FUS GLI1 GPATCH2L GRHL3 GRIP1 H3C1 H4C1 H4C14 H4C16 HABP4 HNF4A HNRNPA1 HNRNPA3 HNRNPK HNRNPR HNRNPU HNRNPUL1 HROB IDH3B IFNAR1 IGSF21 ILF3 IMPDH2 KHDRBS1 KHDRBS2 KHDRBS3 LRIF1 MAP3K5 MBD2 MBP MECOM MED31 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR138-1 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR206 MIR20A MIR20B MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR34A MIR34C MIR363 MIR451A MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MLST8 NCOA1 NCOA2 NCOA3 NOL4 NRIP1 NTAQ1 OFCC1 PDPN PPARA PPDPF PRMT8 QKI RBM15 RELA RNF187 RPL37A RPS29 RUNX1 S100A8 SAMD3 SHLD1 SIRT1 SPAG8 SPEG SPSB1 SPSB2 SRSF1 STAT1 STAT5A STUB1 SUPT5H SYNCRIP TBX6 TERF2 THRB TK1 TOPORS TP53 TRIM48 TUBB UBE4B USP11 VHL VPS72 WDFY3 WDR33 YLPM1 YWHAG ZBTB14 ZCCHC12 ZMYM5 ZNF451
Entrez ID		10094	3276
HPRD ID		09175	04257
Ensembl ID		ENSG00000111229	ENSG00000126457
Uniprot IDs		O15145	Q99873
PDB IDs		6UHC 6YW6 6YW7 8P94	6NT2
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Projection Assembly Negative Regulation Of Actin Filament Bundle Assembly Actin Filament Polymerization Regulation Of Lamellipodium Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Organization Actin Filament Organization Regulation Of Lamellipodium Organization Arp2/3 Protein Complex Actin Polymerization Or Depolymerization Actin Cytoskeleton Actin Filament-based Movement HMG Box Domain Binding Asymmetric Cell Division Protein Polymerization Regulation Of Actin Cytoskeleton Organization Nucleus Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cell Projection Organization Actin Binding Regulation Of Actin Filament-based Process Regulation Of Stress Fiber Assembly Regulation Of Supramolecular Fiber Organization Site Of Double-strand Break	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Extracellular Vesicle Regulation Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of RNA Stability Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Development MRNA Destabilization Negative Regulation Of Cell Differentiation Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Differentiation Negative Regulation Of Cytokine Production
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