SMC4 and NCAPD2

Number of citations of the paper that reports this interaction (PubMedID 10958694)
26

Data Source:
HPRD (in vivo)

		SMC4	NCAPD2
Description		structural maintenance of chromosomes 4	non-SMC condensin I complex subunit D2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Nuclear Chromosome Condensin Complex Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Speck Nuclear Lumen	Nuclear Chromosome Condensed Chromosome, Centromeric Region Condensed Chromosome Condensed Nuclear Chromosome Condensin Complex Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Membrane Centriolar Satellite Ciliary Basal Body
	Molecular Function	Nucleotide Binding Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity	Protein Binding Histone Binding
	Biological Process	Mitotic Sister Chromatid Segregation Nuclear Division Mitotic Chromosome Condensation Meiotic Chromosome Condensation Chromosome Condensation Meiotic Chromosome Segregation Chromosome Organization Cell Division Kinetochore Organization Positive Regulation Of Chromosome Segregation Nuclear Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation	Mitotic Cell Cycle Mitotic Chromosome Condensation Meiotic Chromosome Condensation Chromosome Condensation Cell Division Positive Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation
Pathways		Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes	Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Malaria ( 31844061)
Interacting Genes		6 interacting genes: CEBPA NCAPD2 PTEN SMC2 SUMO2 TRAF3IP1	8 interacting genes: CDC42 CDK1 CNN1 CSNK2A1 ERC1 SMC2 SMC4 SUMO2
Entrez ID		10051	9918
HPRD ID		09276	06472
Ensembl ID		ENSG00000113810	ENSG00000010292
Uniprot IDs		B3KXX5 E9PD53 Q58F29 Q9NTJ3	B3KMS0 B3KY03 Q15021
PDB IDs		4U4P
Enriched GO Terms of Interacting Partners?		Condensin Complex Meiotic Chromosome Condensation Positive Regulation Of Chromosome Condensation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Chromosome Condensation Mitotic Chromosome Condensation Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Chromosome Segregation Nuclear Chromosome Positive Regulation Of Chromosome Separation Condensed Chromosome Chromosome Condensation Condensed Nuclear Chromosome Nucleoplasm Chromosome Organization Involved In Meiotic Cell Cycle Regulation Of Cell Cycle Regulation Of Proteolysis Regulation Of Chromosome Separation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Organelle Organization Positive Regulation Of Catabolic Process Response To Vitamin B2 C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity PML Body Negative Regulation Of Phosphorylation Negative Regulation Of Protein Phosphorylation Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Chromosome Organization Regulation Of Protein Metabolic Process Regulation Of Chromosome Segregation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Regulation Of Osteoblast Differentiation Embryonic Organ Development White Fat Cell Proliferation Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Phosphate Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex	Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Segregation Chromosome Condensation Positive Regulation Of Cell Cycle Process Regulation Of Chromosome Separation Condensin Complex Meiotic Chromosome Condensation Positive Regulation Of Chromosome Condensation Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Positive Regulation Of Chromosome Organization Meiotic Chromosome Segregation Regulation Of Chromosome Condensation Mitotic Chromosome Condensation Kinetochore Organization Regulation Of Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Organelle Organization Protein Localization To Site Of Double-strand Break Positive Regulation Of Chromosome Separation Regulation Of Chromosome Organization Positive Regulation Of Growth Organelle Organization Condensed Nuclear Chromosome Nuclear Chromosome Segregation Chromosome Organization Involved In Meiotic Cell Cycle Pronuclear Fusion Chromosome Organization Nucleotide Binding Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Cell Division DNA Damage Checkpoint Signaling GBD Domain Binding Storage Vacuole Nuclear Division Positive Regulation Of Cellular Component Organization Protein Localization To Chromosome Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Golgi Organization Regulation Of Organelle Organization Chromatin Binding Cyclin-dependent Protein Kinase Activity Supramolecular Fiber Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body
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