PARP2 and HPF1

Number of citations of the paper that reports this interaction (PubMedID 28190768)
48

Data Source:
BioGRID (pull down)

		PARP2	HPF1
Description		poly(ADP-ribose) polymerase 2	histone PARylation factor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Site Of DNA Damage	Chromatin Nucleus Chromosome Site Of DNA Damage
	Molecular Function	DNA Binding Chromatin Binding Damaged DNA Binding Catalytic Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Nucleosome Binding Poly-ADP-D-ribose Binding NAD DNA ADP-ribosyltransferase Activity NAD+-protein-serine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity Poly-ADP-D-ribose Modification-dependent Protein Binding NAD+-protein Mono-ADP-ribosyltransferase Activity	Chromatin Binding Protein Binding Histone Binding Poly-ADP-D-ribose Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity
	Biological Process	DNA Repair Base-excision Repair Double-strand Break Repair DNA Damage Response DNA ADP-ribosylation Decidualization Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Localization To Chromatin Response To Oxygen-glucose Deprivation Extrinsic Apoptotic Signaling Pathway Hippocampal Neuron Apoptotic Process DNA Repair-dependent Chromatin Remodeling	DNA Repair Double-strand Break Repair DNA Damage Response Regulation Of Protein ADP-ribosylation Protein Poly-ADP-ribosylation Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling
Pathways		POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs		Veliparib Olaparib Talazoparib Niraparib Rucaparib
Diseases
GWAS		Menopause (age at onset) ( 26414677)
Interacting Genes		14 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 UBC XRCC1	17 interacting genes: CLCN3 DSCR9 EIF6 FBXO7 H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HMGA1 HMGB1 HMGN1 HMGN2 HMGN4 PARP1 PARP2
Entrez ID		10038	54969
HPRD ID		09660	07924
Ensembl ID		ENSG00000129484	ENSG00000056050
Uniprot IDs		Q9UGN5	Q9NWY4
PDB IDs		3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F 6TX3 6USJ 6X0L 6X0M 6X0N 7AEO 7R59 8HE8 8HKN 8HKO 8HKS 8HLJ 8HLQ 8JNY	6M3G 6M3I 6TX2 6TX3 6X0L 6X0M 6X0N
Enriched GO Terms of Interacting Partners?		Chromosome Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Chromatin Remodeling Nucleosome Organization Chromatin Organization Chromosome Organization Protein-DNA Complex Assembly Negative Regulation Of Chromosome Organization Nucleus Nucleoplasm Protein Localization To Chromosome Telomere Organization Regulation Of Base-excision Repair Negative Regulation Of DNA Metabolic Process Nucleosomal DNA Binding Site Of DNA Damage Protein Heterodimerization Activity DNA Binding Chromosome, Centromeric Region Protein Localization To Chromatin Regulation Of Protein ADP-ribosylation Chromosome, Telomeric Region Poly-ADP-D-ribose Binding Protein-containing Complex Assembly Regulation Of Chromosome Organization Protein-containing Complex Organization Protein Poly-ADP-ribosylation Condensed Chromosome, Centromeric Region Chromatin DNA Repair-dependent Chromatin Remodeling Regulation Of DNA Recombination Cellular Component Assembly Pericentric Heterochromatin Regulation Of Necroptotic Process Organelle Organization Nucleosome Binding Negative Regulation Of Telomere Maintenance Regulation Of Programmed Necrotic Cell Death Chromosome Condensation Protein Localization To Chromosome, Centromeric Region Chromatin Binding Regulation Of DNA Metabolic Process Macrophage Differentiation Double-strand Break Repair NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity	Chromatin Organization Nucleosomal DNA Binding Structural Constituent Of Chromatin Nucleosome Organization Chromatin Remodeling Chromosome Nucleosome Assembly Nucleosome DNA Binding Protein-DNA Complex Assembly Chromosome Organization NAD+-protein-serine ADP-ribosyltransferase Activity DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Chromatin Nucleoplasm Nucleosome Binding Chromatin Binding Base-excision Repair Protein Heterodimerization Activity Nucleus Protein-containing Complex Organization Minor Groove Of Adenine-thymine-rich DNA Binding Damaged DNA Binding Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity DNA Repair Protein-containing Complex Assembly DNA Binding, Bending Epigenetic Regulation Of Gene Expression Protein Poly-ADP-ribosylation NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of DNA Binding Decidualization Telomere Organization DNA Repair-dependent Chromatin Remodeling Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process NAD+ Poly-ADP-ribosyltransferase Activity Regulation Of DNA Recombination Heterochromatin Formation DNA Modification DNA Metabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression, Epigenetic Chromosome Condensation Chromosome, Telomeric Region NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity
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