TEN1 and STN1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		TEN1	STN1
Description		TEN1 subunit of CST complex	STN1 subunit of CST complex
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome CST Complex	Chromosome, Telomeric Region Fibrillar Center Nucleus Nucleoplasm Chromosome Intermediate Filament Cytoskeleton CST Complex
	Molecular Function	DNA Binding Single-stranded DNA Binding Protein Binding Telomerase Inhibitor Activity Telomeric DNA Binding	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding Protein Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding
	Biological Process	Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Replication Regulation Of DNA Metabolic Process
Pathways		Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation	Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation
Drugs
Diseases
GWAS		L-selectin levels ( 25576479)	Chronic obstructive pulmonary disease ( 30804561) Leukocyte telomere length ( 32109421) Myocardial infarction ( 33532862) Systemic lupus erythematosus ( 33272962) Telomere length ( 33941849) Uterine fibroids ( 30194396 31488892) White matter integrity (mean diffusivity) ( 32358547)
Interacting Genes		1 interacting genes: STN1	18 interacting genes: AIRIM APP C14orf119 CDK3 GOLGA2 LRRK2 MFHAS1 MKRN3 MVP NTAQ1 RCOR3 TEN1 TOLLIP TPP1 TRIML2 TUBGCP4 TXN2 ZDHHC17
Entrez ID		100134934	79991
HPRD ID		19459	14872
Ensembl ID		ENSG00000257949	ENSG00000107960
Uniprot IDs		Q86WV5	Q9H668
PDB IDs		4JOI 6W6W 7U5C 8D0B 8D0K 8SOJ 8SOK	4JOI 4JQF 6W6W 7U5C 8D0B 8D0K 8SOJ 8SOK
Enriched GO Terms of Interacting Partners?		Single-stranded Telomeric DNA Binding CST Complex Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Telomere Capping Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Intermediate Filament Cytoskeleton Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Telomere Maintenance Single-stranded DNA Binding Regulation Of DNA Replication Telomere Organization Negative Regulation Of DNA Metabolic Process Fibrillar Center Chromosome, Telomeric Region Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process	Golgi-associated Vesicle Protein Metabolic Process Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Recycling Endosome Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Notch Signaling Pathway Microtubule Nucleation Perforant Pathway To Dendrate Granule Cell Synapse Protein-N-terminal Glutamine Amidohydrolase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Negative Regulation Of Protein Localization To Nucleus
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