MUC16

Description		mucin 16, cell surface associated
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GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Membrane Vesicle Extracellular Exosome
	Molecular Function	Protein Binding
	Biological Process	Cell Adhesion
Pathways		Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis
Drugs		Dimethyl sulfoxide Oregovomab
Diseases
GWAS		Asthma ( 30929738 32296059) Hepcidin/transferrin saturation ratio ( 27846281) Serum cancer antigen 125 (CA 125) levels ( 31666285) Tourette syndrome ( 30818990)
Novel Interacting Genes		5 novel interacting genes: LGALS1 MSLN ODAD3 SUN2 UBC
Interacting Genes		5 interacting genes: LGALS1 MSLN ODAD3 SUN2 UBC
Entrez ID		94025
HPRD ID		07548
Ensembl ID		ENSG00000181143
Uniprot IDs		A0AAG2UXK0 B3KY81 Q8WXI7
PDB IDs		7SA9 8GKL 8VM1 8VRS
Enriched GO Terms of Interacting Partners?		Lactose Binding Positive Regulation Of Dendritic Cell Differentiation Galectin Complex Negative Regulation Of T-helper 17 Cell Lineage Commitment Plasma Cell Differentiation Nuclear Migration Along Microfilament Microtubule-based Transport Nuclear Migration Along Microtubule Nuclear Matrix Organization Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Cytoskeleton-nuclear Membrane Anchor Activity Nuclear Matrix Anchoring At Nuclear Membrane Determination Of Heart Left/right Asymmetry Outer Dynein Arm Docking Complex
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