CARD18

Description		caspase recruitment domain family member 18
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GO Annotations	Cellular Component	Protein-containing Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding Peptidase Inhibitor Activity CARD Domain Binding Caspase Binding
	Biological Process	Proteolysis Inflammatory Response Negative Regulation Of Protein Binding Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS
Novel Interacting Genes		3 novel interacting genes: CARD17P CARD8 DYNC2H1
Interacting Genes		3 interacting genes: CARD17P CARD8 DYNC2H1
Entrez ID		59082
HPRD ID		16099
Ensembl ID		ENSG00000255501
Uniprot IDs		P57730
PDB IDs		1DGN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Production Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production CARD8 Inflammasome Complex NACHT Domain Binding Proteolysis CARD8 Inflammasome Complex Assembly Protein Maturation Negative Regulation Of Cytokine Production NLRP3 Inflammasome Complex Negative Regulation Of NLRP3 Inflammasome Complex Assembly Self Proteolysis Canonical Inflammasome Complex Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway CARD Domain Binding Pyroptotic Cell Death Cysteine-type Endopeptidase Activator Activity Intraciliary Retrograde Transport Minus-end-directed Microtubule Motor Activity Caspase Binding Cytoplasmic Dynein Complex Spinal Cord Motor Neuron Differentiation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Canonical Inflammasome Complex Assembly Protein-containing Complex Protein Metabolic Process Dynein Intermediate Chain Binding 9+2 Motile Cilium Dynein Light Intermediate Chain Binding Dynein Complex Coronary Vasculature Development Cysteine-type Endopeptidase Inhibitor Activity Regulation Of Cytokine Production Pattern Recognition Receptor Activity Cell Differentiation In Spinal Cord Positive Regulation Of Smoothened Signaling Pathway Pyroptotic Inflammatory Response Regulation Of NLRP3 Inflammasome Complex Assembly Ciliary Tip Intraciliary Transport Molecular Condensate Scaffold Activity
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