IGFBP6

Description		insulin like growth factor binding protein 6
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Insulin-like Growth Factor Binary Complex
	Molecular Function	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)
Novel Interacting Genes		40 novel interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 DDX10 DRC4 EFEMP1 EFEMP2 ENKD1 EPDR1 ERBB3 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 MYCBP2 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587
Interacting Genes		40 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 DDX10 DRC4 EFEMP1 EFEMP2 ENKD1 EPDR1 ERBB3 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 MYCBP2 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587
Entrez ID		3489
HPRD ID		00902
Ensembl ID		ENSG00000167779
Uniprot IDs		F8VVA5 P24592
PDB IDs		1RMJ 2JM2
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Exocrine Pancreas Development Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Axon Guidance
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