NR1H4 and SMARCD3

Number of citations of the paper that reports this interaction (PubMedID 14701856)
64

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		NR1H4	SMARCD3
Description		nuclear receptor subfamily 1 group H member 4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleoplasm Receptor Complex	Chromatin Nucleus Nucleoplasm SWI/SNF Complex NpBAF Complex NBAF Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Bile Acid Binding Bile Acid Receptor Activity Sequence-specific DNA Binding Chenodeoxycholic Acid Binding	Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Signaling Receptor Binding Transcription Factor Binding Nuclear Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nitrogen Catabolite Activation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription By RNA Polymerase II Inflammatory Response Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Low-density Lipoprotein Particle Clearance Cell Differentiation Intracellular Receptor Signaling Pathway Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-17 Production Toll-like Receptor 4 Signaling Pathway Regulation Of Urea Metabolic Process Histone H3-R17 Methylation Cellular Triglyceride Homeostasis Bile Acid Signaling Pathway Intracellular Bile Acid Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Bile Acid Biosynthetic Process Cellular Response To Fatty Acid Cellular Response To Organonitrogen Compound Regulation Of Cholesterol Metabolic Process Cellular Response To Bile Acid Positive Regulation Of Phosphatidic Acid Biosynthetic Process Positive Regulation Of Glutamate Metabolic Process	Positive Regulation Of Neuroblast Proliferation Secondary Heart Field Specification Cardiac Right Ventricle Formation Neural Retina Development Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Muscle Cell Differentiation Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Differentiation
Pathways		Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Cytoprotection by HMOX1 Heme signaling
Drugs		alpha-Linolenic acid Ursodeoxycholic acid Farnesol Fexaramine Cholic Acid Deoxycholic acid Taurocholic acid Arachidonic Acid Obeticholic acid Chenodeoxycholic acid (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid Myrrh
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 29403010) Squamous cell carcinoma ( 23341777)	Eyebrow thickness ( 26926045) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) IgG glycosylation ( 23382691) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Multiple myeloma ( 27363682) Red blood cell count ( 32888494)
Interacting Genes		16 interacting genes: APAF1 CASP8 EP300 ESR1 GAPDH H3C1 NCOA1 NCOA6 NCOR2 PPARGC1A RXRA RXRB RXRG SIRT1 SMARCD1 SMARCD3	20 interacting genes: ARHGAP1 CCNE1 ESR1 ESRRA FANCA JUN MAPK14 NR1H4 NR5A1 NR5A2 PBX1 PPARG RARA RARB RARG RORA RXRA SMARCC1 SREBF1 STARD13
Entrez ID		9971	6604
HPRD ID		04827	03440
Ensembl ID		ENSG00000012504	ENSG00000082014
Uniprot IDs		B6ZGS9 F1DAL1 Q96RI1	A0A090N8Z9 Q6STE5
PDB IDs		1OSH 1OSK 3BEJ 3DCT 3DCU 3FLI 3FXV 3GD2 3HC5 3HC6 3L1B 3OKH 3OKI 3OLF 3OMK 3OMM 3OOF 3OOK 3P88 3P89 3RUT 3RUU 3RVF 4OIV 4QE6 4QE8 4WVD 5IAW 5ICK 5Q0I 5Q0J 5Q0K 5Q0L 5Q0M 5Q0N 5Q0O 5Q0P 5Q0Q 5Q0R 5Q0S 5Q0T 5Q0U 5Q0V 5Q0W 5Q0X 5Q0Y 5Q0Z 5Q10 5Q11 5Q12 5Q13 5Q14 5Q15 5Q16 5Q17 5Q18 5Q19 5Q1A 5Q1B 5Q1C 5Q1D 5Q1E 5Q1F 5Q1G 5Q1H 5Q1I 5WZX 5Y1J 5Y44 5Y49 5YXB 5YXD 5YXJ 5YXL 5Z12 6A5W 6A5X 6A5Y 6A5Z 6A60 6HL0 6HL1 6ITM 7D42
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?