CDC20 and KIF18A

Number of citations of the paper that reports this interaction (PubMedID 23288039)
35

Data Source:
BioGRID (enzymatic study)

		CDC20	KIF18A
Description		cell division cycle 20	kinesin family member 18A
Image
GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Anaphase-promoting Complex Centrosome Spindle Cytosol Perinuclear Region Of Cytoplasm	Kinetochore Ruffle Nucleus Cytoplasm Microtubule Organizing Center Kinetochore Microtubule Cytosol Kinesin Complex Microtubule Caveola Microtubule Cytoskeleton Mitotic Spindle Astral Microtubule Mitotic Spindle Midzone
	Molecular Function	Protein Binding Protein C-terminus Binding Anaphase-promoting Complex Binding Enzyme Binding Histone Deacetylase Binding Ubiquitin Ligase Activator Activity	Microtubule Motor Activity Actin Binding Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Microtubule Plus-end Binding Tubulin-dependent ATPase Activity
	Biological Process	Mitotic Sister Chromatid Cohesion Nervous System Development Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Cell Differentiation Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Synaptic Plasticity Regulation Of Meiotic Nuclear Division Regulation Of Dendrite Development Cell Division Positive Regulation Of Synapse Maturation Mitotic Spindle Assembly Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process	Mitotic Sister Chromatid Segregation Microtubule-based Movement Microtubule Depolymerization Mitotic Metaphase Plate Congression Male Meiotic Nuclear Division Protein Transport Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Estradiol Stimulus Seminiferous Tubule Development
Pathways		Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdc20 mediated degradation of Cyclin B SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of Emi1 APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Ub-specific processing proteases Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Antigen processing: Ubiquitination & Proteasome degradation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins Kinesins
Drugs
Diseases
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Age at first birth ( 34211149) Chloride levels ( 29403010) Fulminant type 1 diabetes ( 30552108) Metabolite levels ( 23823483)
Interacting Genes		48 interacting genes: ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC7 APP AURKA BUB1 BUB1B CCNA1 CCNA2 CCNB1 CCT5 CDC16 CDC27 CDC6 CDK1 CDR2 CDT1 DCPS FBXO5 GMNN HDAC1 HDAC2 HSF1 HSF2 KIF18A MAD2L1 MAD2L1BP MAD2L2 NEK2 OTUD7B PIM1 PTTG1 RASSF1 SIRT2 SOSTDC1 SPATC1 TCP1 TGFBR1 TK1 TP63 TRAF1 TRIP13 UBC UBE2C UBE2S	2 interacting genes: CDC20 PPP1CA
Entrez ID		991	81930
HPRD ID		04686	11177
Ensembl ID		ENSG00000117399	ENSG00000121621
Uniprot IDs		Q12834	Q8NI77
PDB IDs		4GGA 4GGC 4GGD 4N14 5G04 5KHR 5KHU 5LCW 6F0X 6Q6G 6Q6H	3LRE 5OAM 5OCU 5OGC
Enriched GO Terms of Interacting Partners?
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