PLPPR4 and EIF4A1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		PLPPR4	EIF4A1
Description		phospholipid phosphatase related 4	eukaryotic translation initiation factor 4A1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Nucleus Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Exosome
	Molecular Function	Phosphatidate Phosphatase Activity Lipid Phosphatase Activity	RNA Cap Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding ATP Hydrolysis Activity
	Biological Process	Phospholipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Axonogenesis Phospholipid Dephosphorylation Inner Ear Development	Cytoplasmic Translational Initiation
Pathways		Lysosphingolipid and LPA receptors	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs			Copper
Diseases
GWAS		Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		2 interacting genes: EIF4A1 FRA10AC1	18 interacting genes: EIF4G1 EIF4G2 EIF4G3 FAM107A LIG4 MAPK6 MYH10 OGT PAIP1 PDCD4 PLPPR4 PRMT1 PRMT5 SUMO2 TNKS UCHL5 UPF2 WDR77
Entrez ID		9890	1973
HPRD ID		07425	04030
Ensembl ID		ENSG00000117600	ENSG00000161960
Uniprot IDs		Q7Z2D5	P60842
PDB IDs			2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW
Enriched GO Terms of Interacting Partners?
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