CEP170 and SDCCAG8

		CEP170	SDCCAG8
Description		centrosomal protein 170	SHH signaling and ciliogenesis regulator SDCCAG8
Image			No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol Microtubule Mitotic Spindle Centriolar Subdistal Appendage	Centrosome Centriole Cytosol Cell-cell Junction Centriolar Satellite Ciliary Basal Body Photoreceptor Cell Cilium
	Molecular Function	Protein Binding	Protein Binding
	Biological Process		Neuron Migration Centrosome Cycle Establishment Of Cell Polarity Cell Projection Organization Microtubule Organizing Center Organization Tube Formation Regulation Of Cilium Assembly
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Bronchopulmonary dysplasia ( 23897914) Chromium levels ( 26025379) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31015462) Lung cancer in ever smokers ( 28604730) Mental health study participation (completed survey) ( 31263887) Metabolite levels ( 23823483) Red cell distribution width ( 32888494 28957414) Schizophrenia ( 23974872) Smoking behaviour (cigarettes smoked per day) ( 31217584) Systemising ( 31508503)	Adult body size ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 31152163 29124443) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 28135244 27841878 30578418) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate (creatinine) ( 26831199) Mean platelet volume ( 32888494) Mental health study participation (completed survey) ( 31263887) Metabolite levels ( 23823483) Multisite chronic pain ( 33830993) Obesity (early onset extreme) ( 20421936) Platelet distribution width ( 32888494) Pulse pressure ( 30578418) Schizophrenia ( 25056061 29483656 30285260 23974872) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Self-reported risk-taking behaviour ( 30271922) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Toenail selenium levels ( 25343990) Walking pace ( 33128006)
Interacting Genes		9 interacting genes: NDEL1 PPP1CA PTEN SDCCAG8 SNAPIN SRPK2 VAV2 YWHAG YWHAQ	5 interacting genes: AKT3 CEP170 FBXO7 RGS7 TNS2
Entrez ID		9859	10806
HPRD ID		17172	10215
Ensembl ID		ENSG00000143702	ENSG00000054282
Uniprot IDs		Q5SW79	Q86SQ7
PDB IDs		4JON
Enriched GO Terms of Interacting Partners?
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