EPM2AIP1 and ARHGEF5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		EPM2AIP1	ARHGEF5
Description		EPM2A interacting protein 1	Rho guanine nucleotide exchange factor 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection Cell Periphery
	Molecular Function	Protein Binding Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding
	Biological Process	Response To Insulin Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycogen (starch) Synthase Activity	Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Positive Regulation Of Protein Import
Pathways			NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Subjective response to lithium treatment ( 26503763) Triglyceride levels ( 32203549)	Breast cancer ( 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		46 interacting genes: ACTN1 APPL2 ARHGEF5 C1orf50 CBFA2T3 CCNB1IP1 CNTROB CPSF7 DTX3 EMP2 EPM2A FHL3 GFAP HSF2BP KCTD1 KCTD9 KRT16 KRT75 LDB2 LIN52 LNX1 MAD2L1 MEOX2 MX1 NOC4L OTUD7B PICK1 PRTFDC1 PSMA7 RBMY1F RBMY1J REL SERPINF1 SWSAP1 TFIP11 TNFAIP1 TNKS TRA2B TRIM50 TRIM54 USP54 VPS52 ZBTB14 ZIM2 ZNF620 ZSCAN18	29 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 EFHC2 EPM2AIP1 FKBP8 HSF2BP HSPBAP1 LMO2 LRATD1 MB21D2 MID2 NR4A1 PICK1 PLCG1 PLEKHG4 POLR1C RHOA SEPHS2 SLAIN1 SLU7 TBC1D13 TCF4 TRIM27 TRIM54 ZRANB1
Entrez ID		9852	7984
HPRD ID		07445	02932
Ensembl ID		ENSG00000178567	ENSG00000050327
Uniprot IDs		Q7L775	Q12774
PDB IDs
Enriched GO Terms of Interacting Partners?
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