GAB2 and ETV6

Number of citations of the paper that reports this interaction (PubMedID 15143164)
15

Data Source:
HPRD (in vitro, in vivo)

		GAB2	ETV6
Description		GRB2 associated binding protein 2	ETS variant transcription factor 6
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Chromatin Nucleus Nucleolus Cytosol Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Osteoclast Differentiation Positive Regulation Of Mast Cell Degranulation Phosphatidylinositol-mediated Signaling	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Vitellogenesis Neurogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Proliferation Mesenchymal Cell Apoptotic Process
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Constitutive Signaling by Aberrant PI3K in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Interleukin-15 signaling Interleukin receptor SHC signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants	Signaling by membrane-tethered fusions of PDGFRA or PDGFRB Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alzheimer's disease (late onset) ( 17553421) Alzheimer's disease (survival time) ( 25649651) Aspartate aminotransferase levels ( 33547301) Blond vs. brown/black hair color ( 30531825) Body mass index ( 28892062) Brown vs. black hair color ( 30531825) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Creatine kinase levels ( 29403010) Creatinine levels ( 29403010) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Hair color ( 29662168) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29785010) Lactate dehydrogenase levels ( 29403010) LDL cholesterol ( 30275531) Lipid traits (pleiotropy) (HIPO component 2) ( 30289880) Menarche (age at onset) ( 21102462 25231870) Platelet distribution width ( 32888494) Testicular germ cell tumor ( 28604728 28604732 26503584) Total cholesterol levels ( 30275531) Tourette syndrome ( 30818990) Triglyceride levels ( 32203549) Triglycerides ( 30275531)	Alanine aminotransferase levels ( 33547301) Asthma ( 27611488) Body size at age 10 ( 32376654) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Colorectal cancer ( 27145994) Eye color ( 33692100) Height ( 28552196 20881960 25282103 23563607 31562340 18391951) Hematocrit ( 32888494) Hemoglobin ( 32888494) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nicotine dependence symptom count ( 25555482) Night sleep phenotypes ( 27126917) Phosphorus levels ( 29403010) Red blood cell count ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		30 interacting genes: AKT1 ARHGAP32 CD247 CRKL EPOR ETV6 GAB1 GRAP GRAP2 GRB2 INPP5D LAT LCK LYN MAPK1 MAPK3 MAPK4 MYO15B NCK1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SHC1 SRC SYK TENM4 TNFRSF11A ZAP70	21 interacting genes: AP1M1 AXIN1 CD27 CRKL FBXL6 FLI1 GAB2 GRB2 HDAC9 KAT5 L3MBTL1 NFE2L2 NSD3 NTAQ1 PIN1 SIN3A SMURF1 SUMO1 TRAF2 TUBA4A UBE2I
Entrez ID		9846	2120
HPRD ID		05866	15976
Ensembl ID		ENSG00000033327	ENSG00000139083
Uniprot IDs		Q9UQC2	A0A0S2Z3C9 P41212
PDB IDs		2VWF 2W0Z 5EWZ 5EXA 6Y3R 6Y3S	1JI7 1LKY 2DAO 2QAR 2QB0 2QB1 5L0P 7JU2
Enriched GO Terms of Interacting Partners?
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