PLEKHM1 and GADD45G

Number of citations of the paper that reports this interaction (PubMedID 15383276)
151

Data Source:
BioGRID (two hybrid)

		PLEKHM1	GADD45G
Description		pleckstrin homology and RUN domain containing M1	growth arrest and DNA damage inducible gamma
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GO Annotations	Cellular Component	Nucleolus Lysosome Lysosomal Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle Autolysosome	Nucleus Cytoplasm
	Molecular Function	Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Protein Transport Lysosome Localization Intracellular Signal Transduction Positive Regulation Of Bone Resorption Autophagosome-lysosome Fusion Positive Regulation Of Ruffle Assembly Late Endosome To Lysosome Transport	Apoptotic Process Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of P38MAPK Cascade
Pathways
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Cortical volume ( 32963231) Daytime nap ( 33568662) Epithelial ovarian cancer ( 25581431) Hip circumference ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Male-pattern baldness ( 29146897 28196072) Monocyte count ( 32888494) Neuroticism ( 29255261) Parkinson's disease ( 20070850) Remission after SSRI treatment in MDD or neuroticism ( 29559929)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Automobile speeding propensity ( 30643258) Brain morphology (MOSTest) ( 32665545) Fibrinogen levels ( 28107422 26561523) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolic syndrome ( 31589552) Nonsyndromic cleft lip with cleft palate ( 28232668) Protein quantitative trait loci ( 18464913) Thyroglobulin plasma levels ( 30929638) Triglyceride levels ( 32203549 32154731)
Interacting Genes		10 interacting genes: BID CTDSP1 EIF2S2 GADD45G MAPK6 MOB4 MUC2 PAFAH1B3 SERPINB9 TRIM54	74 interacting genes: ACTN1 AFAP1L1 APP ARPC5L BEND7 BLOC1S2 CCNB1 CDK1 CDKN1A CEP57L1 CFAP44 CNOT9 CRIP2 DCTN2 DDAH2 DDIT4L EEF1A1 EEF1G EIF3G ENKD1 ESR1 EZH2 FAM156A FAM156B GABBR2 GADD45B GADD45GIP1 GDF9 GRAMD4 HAP1 HNRNPAB HP IKBKG KAT5 LRIF1 LUC7L LUC7L2 MAP3K4 MED31 MIDN NMB PCNA PDE4DIP PDIA4 PHAX PIAS4 PLEKHM1 PPARA PPARD PPARG PPIL1 PTN PTPRK RAN RARA RASSF10 RBM48 RCN1 RDH13 REL RRP7A RWDD2B RXRA SERPINA4 SGK1 SH3GLB1 SH3GLB2 SMARCB1 TRMT2A TSNAX UTP14A ZNF579 ZNF664 ZNF763
Entrez ID		9842	10912
HPRD ID		11439	05383
Ensembl ID		ENSG00000225190	ENSG00000130222
Uniprot IDs		Q9Y4G2	O95257
PDB IDs		5DPR 5DPS 5DPT 5DPW	2WAL 3FFM
Enriched GO Terms of Interacting Partners?
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