ARHGEF11 and LPAR2

Number of citations of the paper that reports this interaction (PubMedID 15755723)
44

Data Source:
HPRD (in vitro, in vivo)

		ARHGEF11	LPAR2
Description		Rho guanine nucleotide exchange factor 11	lysophosphatidic acid receptor 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle
	Molecular Function	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding	G Protein-coupled Receptor Activity Protein Binding Lipid Binding Lysophosphatidic Acid Receptor Activity
	Biological Process	Regulation Of Cell Growth Striated Muscle Contraction G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Transcription, DNA-templated Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Metabolic Process
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Height ( 31562340) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Schizophrenia ( 23974872) Sphingolipid levels ( 22359512)
Interacting Genes		16 interacting genes: ABCA1 CDC42 GNA12 GNA13 LPAR1 LPAR2 MAP1A MAP1B NEK2 PLXNB1 PLXNB2 PLXNB3 PTPRF RHOA RPS6KA1 SLC1A6	7 interacting genes: ARHGEF11 ARHGEF12 ATXN1 GIPC1 SLC9A3R1 SLC9A3R2 TRIP6
Entrez ID		9826	9170
HPRD ID		09302	05487
Ensembl ID		ENSG00000132694	ENSG00000064547
Uniprot IDs		O15085	A0A024R7M9 Q9HBW0
PDB IDs		1HTJ 1XCG 2DLS 3KZ1 3T06 5E6P 5JHG 5JHH 5TYT	4P0C
Enriched GO Terms of Interacting Partners?
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