MAML1 and NOTCH4

Number of citations of the paper that reports this interaction (PubMedID 11101851)
202

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		MAML1	NOTCH4
Description		mastermind like transcriptional coactivator 1	notch receptor 4
Image			No pdb structure
GO Annotations	Cellular Component	MAML1-RBP-Jkappa- ICN1 Complex Nucleus Nucleoplasm Nuclear Speck Intracellular Membrane-bounded Organelle	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Transcription Coactivator Activity Protein Binding Protein Kinase Binding Peptide Antigen Binding	Notch Binding Calcium Ion Binding Protein Binding Signaling Receptor Activity
	Biological Process	Atrioventricular Node Development Protein Phosphorylation Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Myotube Differentiation Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Atrioventricular Node Cell Development	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Cell Fate Determination Morphogenesis Of A Branching Structure Epithelial To Mesenchymal Transition Endothelial Cell Morphogenesis Vasculature Development Positive Regulation Of Transcription Of Notch Receptor Target Hemopoiesis Cell Differentiation Mammary Gland Development Wound Healing Negative Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Negative regulation of NOTCH4 signaling
Drugs
Diseases
GWAS		Dental caries (decayed and filled deciduous teeth) ( 31533690) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Neutrophil count ( 27863252) Resting heart rate ( 24680774) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)	Advanced glycation end-product levels ( 26083729) Age-related macular degeneration ( 22694956) Aspartate aminotransferase levels ( 29403010) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Blood protein levels in cardiovascular risk ( 28369058) Body shape index ( 34021172) Chronic hepatitis B infection ( 25802187) Circulating myeloperoxidase levels (serum) ( 23620142) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Colorectal cancer ( 30529582) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Food antigen IgG levels ( 24962563) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Iron status biomarkers (iron levels) ( 28334935) Joint mobility (Beighton score) ( 27182965) Longevity ( 30294719) Lung cancer ( 31577861 28604730) Lung cancer in ever smokers ( 28604730) Lupus nephritis in systemic lupus erythematosus ( 24925725) Migraine ( 27322543) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Obesity-related traits ( 23251661) Objective response to lithium treatment in bipolar disorder ( 26503763) Prostate cancer ( 23535732) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 19571808 30285260 23894747) Squamous cell lung carcinoma ( 28604730) Systemic lupus erythematosus ( 21408207 32771030) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Type 1 diabetes (age at diagnosis) ( 33179336) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 24837172 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		12 interacting genes: CDK8 CREBBP EP300 HDAC9 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PIAS1 RBPJ SLIT3 TP53	22 interacting genes: DLL4 EGFL7 ELOC FBXW7 MAML1 MAML2 MAML3 MSH5 NEU1 NFKBIL1 NFYA PBX2 PSEN1 PSEN2 PSMB8 RBPJ SLC27A4 SMAD2 SMAD3 SMAD4 TDP2 WWP2
Entrez ID		9794	4855
HPRD ID		05665	01290
Ensembl ID		ENSG00000161021	ENSG00000204301
Uniprot IDs		Q92585	A0A1U9X983 Q99466
PDB IDs		2F8X 3NBN 3V79 6SMV
Enriched GO Terms of Interacting Partners?
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