EIF4A3 and CWC22

Number of citations of the paper that reports this interaction (PubMedID 29395067)
145

Data Source:
BioGRID (pull down, x-ray crystallography, fluorescent resonance energy transfer, affinity chromatography technology, proximity labelling technology)

		EIF4A3	CWC22
Description		eukaryotic translation initiation factor 4A3	CWC22 spliceosome associated protein homolog
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Glutamatergic Synapse Postsynaptic Cytosol	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Nuclear Speck U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding RNA Helicase Activity MRNA Binding Protein Binding ATP Binding Poly(A) Binding ATP Hydrolysis Activity Selenocysteine Insertion Sequence Binding RNA Stem-loop Binding Ribonucleoprotein Complex Binding Translation Regulator Activity	RNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome RRNA Processing Associative Learning Response To Organic Cyclic Compound Negative Regulation Of Translation Exploration Behavior Positive Regulation Of Translation Embryonic Cranial Skeleton Morphogenesis MRNA Transport Cellular Response To Selenite Ion Negative Regulation Of Excitatory Postsynaptic Potential Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Selenocysteine Incorporation Negative Regulation Of Selenocysteine Insertion Sequence Binding Cellular Response To Brain-derived Neurotrophic Factor Stimulus	MRNA Splicing, Via Spliceosome Regulation Of MRNA Splicing, Via Spliceosome
Pathways		ISG15 antiviral mechanism Transport of Mature mRNA derived from an Intron-Containing Transcript Deadenylation of mRNA mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 26708285) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Adult body size ( 32376654) Body mass index ( 28892062) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Schizophrenia ( 30285260)
Interacting Genes		35 interacting genes: CARD9 CASC3 CCDC174 CCR6 CDCA7L CNKSR3 CWC22 DDIT4L DDX56 DISC1 DRG2 EHMT2 ERCC6 ESR1 HTR6 LNX1 MAGOH MEOX1 MEOX2 NIF3L1 NXF1 PAX4 PDCD4 PICK1 POLR2G PRMT5 PSMA1 RBM8A REL TRIM27 UPF1 UPF3B VRTN YWHAQ ZXDB	4 interacting genes: EIF4A3 EXOSC8 KLHL2 PTPN21
Entrez ID		9775	57703
HPRD ID		06482	17220
Ensembl ID		ENSG00000141543	ENSG00000163510
Uniprot IDs		A0A024R8W0 I3L3H2 P38919	Q9HCG8
PDB IDs		2HXY 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 4C9B 5MQF 5XJC 5YZG 6ICZ 6QDV 6YVH 7A5P	4C9B 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF7 6ICZ 6QDV 6YVH 6ZYM 7A5P
Enriched GO Terms of Interacting Partners?
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