BCLAF1 and LEMD3

Number of citations of the paper that reports this interaction (PubMedID 15681850)
54

Data Source:
HPRD (in vitro, in vivo)

		BCLAF1	LEMD3
Description		BCL2 associated transcription factor 1	LEM domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mediator Complex Nuclear Speck	Nuclear Inner Membrane Integral Component Of Nuclear Inner Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	DNA Binding Transcription Coregulator Activity RNA Binding Protein Binding	Protein Binding Chromatin DNA Binding
	Biological Process	Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Initiation Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Nuclear Envelope Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction
Pathways			Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerisation of the Nuclear Lamina RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Height ( 31562340) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		11 interacting genes: BCL2 BCL2L1 CHD1 CLK1 CSNK2A1 EMD LEMD3 OGT PIN1 SRPK2 YWHAG	7 interacting genes: BCLAF1 RABAC1 REEP4 SMAD1 SMAD2 SMAD3 SMAD9
Entrez ID		9774	23592
HPRD ID		16544	09704
Ensembl ID		ENSG00000029363	ENSG00000174106
Uniprot IDs		Q9NYF8	A0A024RBB9 Q9Y2U8
PDB IDs			2CH0 5ZOJ 5ZOK
Enriched GO Terms of Interacting Partners?
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