UTP14C and NUDT15

		UTP14C	NUDT15
Description		UTP14C small subunit processome component	nudix hydrolase 15
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytosol Small-subunit Processome	Cytosol
	Molecular Function	Protein Binding	Protein Binding 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Nucleoside-diphosphatase Activity NADH Pyrophosphatase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity DTTP Diphosphatase Activity Metal Ion Binding Nucleoside-triphosphate Diphosphatase Activity
	Biological Process	RRNA Processing Spermatogenesis Cell Differentiation Meiotic Cell Cycle	Mitotic Cell Cycle Response To Reactive Oxygen Species Purine Nucleotide Catabolic Process DGTP Catabolic Process Xenobiotic Catabolic Process DNA Protection Nucleobase-containing Small Molecule Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Nucleoside Phosphate Catabolic Process
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	Phosphate bond hydrolysis by NUDT proteins
Drugs
Diseases
GWAS			Estimated glomerular filtration rate ( 31015462) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		32 interacting genes: ALAS1 BICD2 C8orf34 CARD10 CCDC57 CEP70 GCC1 GOLGA2 GOLGA6A HOOK1 HOOK2 JRK KANK2 KRT34 KRT40 LZTS2 MCC MEOX2 MTUS2 NAB2 NUDT15 PDE4DIP PIBF1 PRICKLE1 RABEP1 RINT1 TEX11 TRAF1 TRAF2 TRIM27 TRIM54 TXLNA	6 interacting genes: CDADC1 FNDC3A GABARAPL2 MTRF1 SRD5A3 UTP14C
Entrez ID		9724	55270
HPRD ID		12346	14848
Ensembl ID		ENSG00000253797	ENSG00000136159
Uniprot IDs		A0A024RDV0 Q5TAP6	Q9NV35
PDB IDs			5BON 5LPG 6T5J
Enriched GO Terms of Interacting Partners?
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