KDM4A and MMACHC

		KDM4A	MMACHC
Description		lysine demethylase 4A	metabolism of cobalamin associated C
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytosol	Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Histone Demethylase Activity Histone H3-methyl-lysine-9 Demethylase Activity Methylated Histone Binding Histone H3-methyl-lysine-36 Demethylase Activity	Protein Binding Oxidoreductase Activity Transferase Activity Cobalamin Binding Demethylase Activity Cyanocobalamin Reductase (cyanide-eliminating) Activity Protein Homodimerization Activity Glutathione Binding FAD Binding
	Biological Process	Chromatin Remodeling Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cardiac Muscle Hypertrophy In Response To Stress Histone Demethylation Response To Nutrient Levels Histone H3-K9 Demethylation Positive Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Cell Death Histone H3-K36 Demethylation Negative Regulation Of Histone H3-K9 Trimethylation	Glutathione Metabolic Process Cobalamin Metabolic Process Demethylation
Pathways		HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
Drugs			Cyanocobalamin Hydroxocobalamin
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Household income (MTAG) ( 31844048) Menarche (age at onset) ( 25231870) Number of sexual partners ( 30643258) Perceived intensity of sweet substances ( 31005972) Red blood cell count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730)	Blood protein levels ( 28240269) Homocysteine levels ( 23824729)
Interacting Genes		15 interacting genes: EIF2B3 EIF3I H3C1 H4C1 IPO13 KIF2C MAST2 MMACHC PIK3R3 PPIH RB1 RNF168 RNF8 ST3GAL3 TSPAN1	2 interacting genes: KDM4A MMADHC
Entrez ID		9682	25974
HPRD ID		17168	18585
Ensembl ID		ENSG00000066135	ENSG00000132763
Uniprot IDs		O75164	A0A0C4DGU2 Q9Y4U1
PDB IDs		2GF7 2GFA 2GP3 2GP5 2OQ6 2OQ7 2OS2 2OT7 2OX0 2P5B 2PXJ 2Q8C 2Q8D 2Q8E 2QQR 2QQS 2VD7 2WWJ 2YBK 2YBP 2YBS 3NJY 3PDQ 3RVH 3U4S 4AI9 4BIS 4GD4 4URA 4V2V 4V2W 5A7N 5A7O 5A7P 5A7Q 5A7S 5A7W 5A80 5ANQ 5D6W 5D6X 5D6Y 5F2S 5F2W 5F32 5F37 5F39 5F3C 5F3E 5F3G 5F3I 5F5I 5FPV 5FWE 5FY8 5FYC 5FYH 5FYI 5LY1 5LY2 5TVR 5TVS 5VAR 5VGI 5VMP 6CG1 6CG2 6G5W 6G5X 6H4O 6H4P 6H4Q 6H4R 6H4S 6H4T 6H4U 6H4V 6H4W 6H4X 6H4Y 6H8P 6HGT 7D4A	3SBY 3SBZ 3SC0 3SOM 5UOS
Enriched GO Terms of Interacting Partners?
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