CD58 and HERPUD1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CD58	HERPUD1
Description		CD58 molecule	homocysteine inducible ER protein with ubiquitin like domain 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Endoplasmic Reticulum Quality Control Compartment Lewy Body Core
	Molecular Function	Signaling Receptor Binding Protein Binding	Molecular_function Protein Binding Transmembrane Transporter Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Positive Regulation Of Interleukin-8 Production Heterotypic Cell-cell Adhesion Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion	Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Targeting To ER Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Cell surface interactions at the vascular wall Neutrophil degranulation	ATF4 activates genes in response to endoplasmic reticulum stress
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244 22190364 21244703 24076602 19525953 19525955 21833088 27386562) Primary biliary cholangitis ( 28425483) Systemic lupus erythematosus ( 33272962 33536424)	Aspartate aminotransferase levels ( 33547301) Cardiovascular risk factors ( 20838585) Coronary artery disease ( 29212778) Diisocyanate-induced asthma ( 25918132) HDL cholesterol ( 20031564 23505323 24886709) HDL Cholesterol in HIV-infection ( 25884002) HDL cholesterol levels ( 26763881 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels in HIV infection ( 33109212) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010 33339817) Hip circumference adjusted for BMI ( 34021172) Hypo-HDL-cholesterolemia ( 31087446) LDL cholesterol levels ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 33339817) Low HDL-cholesterol levels ( 31910446) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Serum metabolite levels ( 33031748) Total cholesterol levels ( 29403010 33339817) Triglyceride levels ( 29403010 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		4 interacting genes: APP CD2 DNAJA1 HERPUD1	20 interacting genes: AMFR APP ARHGDIA C5AR2 CCR2 CD3D CD58 CHRM2 EWSR1 F2RL1 IMPA2 PSEN1 RPA2 SH3RF1 STARD9 TOLLIP UBQLN2 USP7 VCP XRCC6
Entrez ID		965	9709
HPRD ID		01081	07456
Ensembl ID		ENSG00000116815	ENSG00000051108
Uniprot IDs		P19256	A4UAE9 Q15011 Q53FP9
PDB IDs		1CCZ 1CI5 1QA9	1WGD
Enriched GO Terms of Interacting Partners?
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