CTR9 and H1-2

Number of citations of the paper that reports this interaction (PubMedID 24360965)
27

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		CTR9	H1-2
Description		CTR9 homolog, Paf1/RNA polymerase II complex component	H1.2 linker histone, cluster member
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cdc73/Paf1 Complex Nuclear Speck Transcriptionally Active Chromatin	Nucleosome Euchromatin Nucleus Transcriptionally Active Chromatin
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding SH2 Domain Binding	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Inner Cell Mass Cell Differentiation Trophectodermal Cell Differentiation Blastocyst Growth Blastocyst Hatching Regulation Of Transcription, DNA-templated Transcription Elongation From RNA Polymerase II Promoter Receptor Signaling Pathway Via JAK-STAT Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Population Maintenance Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Histone H3-K4 Trimethylation Negative Regulation Of MRNA Polyadenylation Regulation Of Genetic Imprinting Positive Regulation Of Histone H3-K79 Methylation Positive Regulation Of Histone H2B Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Negative Regulation Of DNA Recombination Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Migraine ( 27182965) Sleep (1/3-day periodicity) ( 33075057)
Interacting Genes		7 interacting genes: BLK CNTNAP2 H1-2 SMAD9 SOX4 SUMO2 TCEA1	29 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 HELLS IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 SNCA VHL WDR12 YBX1
Entrez ID		9646	3006
HPRD ID		06717	07514
Ensembl ID		ENSG00000198730	ENSG00000187837
Uniprot IDs		Q6PD62	P16403
PDB IDs		5ZYQ 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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