NFE2L3 and NFE2L1

Number of citations of the paper that reports this interaction (PubMedID 23661758)
66

Data Source:
BioGRID (fluorescent resonance energy transfer)

		NFE2L3	NFE2L1
Description		nuclear factor, erythroid 2 like 3	nuclear factor, erythroid 2 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Heme Biosynthetic Process Cholesterol Metabolic Process Anatomical Structure Morphogenesis Cellular Response To Oxidative Stress
Pathways
Drugs			Dodecyldimethylamine N-oxide
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549 33730874) Apolipoprotein B levels ( 32203549) Body mass index ( 23583978) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Endometriosis ( 28333195) Gamma glutamyl transferase levels ( 29403010 33339817) Height ( 31562340) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 29403010 33339817) Obesity-related traits ( 23251661) Phoneme awareness ( 30741946) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Superior frontal gyrus grey matter volume ( 25335168) Total cholesterol levels ( 29403010 33339817) Triglyceride levels ( 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Aspartate aminotransferase levels ( 33547301) Fasting glucose ( 34059833) Generalized epilepsy ( 22949513) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		8 interacting genes: BACH2 CREB3 GSK3B MAFK NFE2 NFE2L1 NFE2L2 PPARG	16 interacting genes: ATF4 BACH2 CAPN1 CD6 CREBZF GSK3B HCFC1 JUN JUNB JUND MAFF MAFG MAFK NFE2L3 PARVA TULP3
Entrez ID		9603	4779
HPRD ID		09162	01223
Ensembl ID		ENSG00000050344	ENSG00000082641
Uniprot IDs		Q9Y4A8	J9JIE5 Q14494 Q8NF22
PDB IDs
Enriched GO Terms of Interacting Partners?
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