BCAR1 and CSPG4

Number of citations of the paper that reports this interaction (PubMedID 10587647)
67

Data Source:
HPRD (in vitro, in vivo)

		BCAR1	CSPG4
Description		BCAR1 scaffold protein, Cas family member	chondroitin sulfate proteoglycan 4
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium Axon	Ruffle Extracellular Region Nucleoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Apical Plasma Membrane Lamellipodium Membrane Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding	Coreceptor Activity Protein Kinase Binding
	Biological Process	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis Endothelin Receptor Signaling Pathway Actin Filament Reorganization	Angiogenesis Substrate-dependent Cell Migration Cell Population Proliferation Glial Cell Migration Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Platelet-derived Growth Factor Receptor Signaling Pathway Tissue Remodeling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Ruffle Assembly
Pathways		Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Coronary artery disease ( 33020668) Crohn's disease (time to surgery) ( 23665963) Intracranial aneurysm ( 33199917) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Pancreatic cancer ( 29422604 25086665) Type 1 diabetes ( 25751624) Type 2 diabetes ( 22885922 29358691 30297969)	Estimated glomerular filtration rate ( 31015462) Hip index ( 34021172) Intraocular pressure ( 29617998) Simvastatin-induced myopathy ( 31220337)
Interacting Genes		65 interacting genes: ABL1 AJUBA ANKS1A ARHGAP32 BMX CASP3 CD2AP COPB1 CRK CRKL CSPG4 DOCK1 DOK7 E2F2 EFS ESR1 FAM102A FAM90A1 FES FXYD6 FYB1 FYN GLIS2 GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NCK2 NEDD9 NPHP1 PIK3R1 PKD1 PLPP3 PPP1R15A PRAM1 PTEN PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TNS3 TRIP6 TUBA4A UHRF2 USP2 VCL VPS11 YES1 YWHAZ	9 interacting genes: ATF7IP BCAR1 C1QA CDC42 GRIP1 GRIP2 MPDZ PTK2 TNK2
Entrez ID		9564	1464
HPRD ID		04248	03105
Ensembl ID		ENSG00000050820	ENSG00000173546
Uniprot IDs		B3KWE2 P56945	Q6UVK1
PDB IDs		1WYX 3T6G 5O2M 5O2P 5O2Q
Enriched GO Terms of Interacting Partners?
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