RASAL2 and MCC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RASAL2	MCC
Description		RAS protein activator like 2	MCC regulator of WNT signaling pathway
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Lamellipodium Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Signal Transduction Regulation Of GTPase Activity	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of RAS by GAPs RND3 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744) Body mass index ( 26426971 19079260) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Immune response to smallpox vaccine (IL-6) ( 22542470) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Weight ( 19079260)	Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		9 interacting genes: HMGB1 MCC MEOX2 MIA2 NFKBIB TRAF1 UBC USHBP1 YWHAG	80 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CSNK1E CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 IMP3 KAT5 KIF3C KIFC3 LRRC45 MAGEE1 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 STOML2 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792
Entrez ID		9462	4163
HPRD ID		05845	01157
Ensembl ID		ENSG00000075391	ENSG00000171444
Uniprot IDs		A8K2P3 Q9UJF2	P23508
PDB IDs			6MTU 6MTV
Enriched GO Terms of Interacting Partners?
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